Effect of PLGA( poly lactic Co-glycolic acid) system loaded with Deferoxamine in Osteonecrosis of the femur head

Comparative study of the effectiveness of the PLGA( poly lactic Co-glycolic acid) system loaded with Deferoxamine with Core decompression alone in treatment of patients with early stage of Osteonecrosis of the femur head

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161121031003N3

Enrollment

Registered

2019-04-16

Start date

2019-01-21

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteonecrosis of the femoral head. Juvenile osteochondrosis of hip and pelvis, unspecified

Interventions

Intervention 1: Intervention group: Patients in the intervention group after admission in the operating room according to the location of the osteonecrosis indicated in radiography, MRI and CT Scan wi

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age > 18 years ARCO stage 1 or 2 Idiopathic, steroid and alcohol induced, associated with lupus and sickel cell anemia

Exclusion criteria

Exclusion criteria: Age> 50 years previous history of pelvic surgery An underlying condition that prevents surgery such as heart or lung disease

Design outcomes

Primary

Measure	Time frame
Femoral head necrosis rate. Timepoint: At the beginning of the study (before the intervention) and 6 months and 12 months after the intervention, the hip joint MRI will be performed. Method of measurement: MRI.	—

Secondary

Measure	Time frame
Clinical status of patients. Timepoint: All patients will be examined prior to the intervention and at intervals of 2 weeks and 1-3-6 and 12 months after the intervention. Method of measurement: modified merle dAubigne scale.;Pain. Timepoint: All patients will be examined prior to the intervention and at intervals of 2 weeks and 1-3-6 and 12 months after the intervention. Method of measurement: visual analog score.;Cysts and subchondral sclerosis. Timepoint: All patients will be examined prior to the intervention and at intervals of 2 weeks and 1-3-6 and 12 months after the intervention. Method of measurement: pelvic radiography.;The amount of collapse in femural head. Timepoint: At the beginning of the study (before the intervention) and 6 months and 12 months after the intervention. Method of measurement: Pelvic CT Scane.	—

Measure

Time frame

Clinical status of patients. Timepoint: All patients will be examined prior to the intervention and at intervals of 2 weeks and 1-3-6 and 12 months after the intervention. Method of measurement: modified merle dAubigne scale.;Pain. Timepoint: All patients will be examined prior to the intervention and at intervals of 2 weeks and 1-3-6 and 12 months after the intervention. Method of measurement: visual analog score.;Cysts and subchondral sclerosis. Timepoint: All patients will be examined prior to the intervention and at intervals of 2 weeks and 1-3-6 and 12 months after the intervention. Method of measurement: pelvic radiography.;The amount of collapse in femural head. Timepoint: At the beginning of the study (before the intervention) and 6 months and 12 months after the intervention. Method of measurement: Pelvic CT Scane.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajad Noori Garavand

Iran University of Medical Sciences

Gharanizadeh.k@iums.ac.ir+98 21 3354 2005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 8, 2026