Burn. Burns and corrosions
Conditions
Interventions
Intervention 1: The control group will receive placebo for 12 weeks. Intervention 2: The intervention group will recieve 80 mg propranolol / day for 12 weeks and then gradually tapered to discontinue
Placebo
Treatment - Drugs
The control group will receive placebo for 12 weeks
The intervention group will recieve 80 mg propranolol / day for 12 weeks and then gradually tapered to discontinue in 1 week
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: We will include 18 to 50 years old patients experiencing electrical injury 15 days to 3 months prior to the study. Exclusion criteria are as follows: positive history of joint or bone disease; neuropathy (central or peripheral); diabetes mellitus or consumption of any drug affecting the autonomic nervous system; any cast; skin lesion, skin graft, or scar at the sites of SSR recording or stimulus (palms, soles, wrists, or ankles) that make technical problems for SSR recording; contraindications of propranolol administration such as bronchial asthma, pronounced bradycardia, manifest heart failure, second and third degree heart block, hypersensitivity to propranolol. Any patient with evidence of peripheral neuropathy on 4 limb electrophysiologic study (done at the beginning of the study after filling in the written informed consent).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mass desitometery. Timepoint: Before study and 3 months, 9 months after study. Method of measurement: Bone mass densitometery.;Sympathetic skin response. Timepoint: Before study and 3 months, 9 months after study. Method of measurement: SSR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decreased blood pressure. Timepoint: Before and every 2 weeks after study. Method of measurement: Mesurment of blood pressure. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZohreh Eshghi
Shiraz University of Medical Sciences
Outcome results
None listed