Remifentanil infusion effect on oocyte retrieval

Comparison of anesthesia by Remifentanil with or without Propofol for Transvaginal Ultrasonography Oocyte Retrieval (TUGOR) on pregnancy and anesthesia outcomes in patients candidate for in vitro fertilization

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201611177013N15

Enrollment

180

Registered

2016-12-24

Start date

2016-12-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anethestics complication and efficacy. Complications of anaesthesia during pregnancy

Interventions

Intervention 1: Intervention group: 0.25 µg/kg/min remifentanil will be infused during operation. Intervention 2: Control group: 1 µg/kg/min remifentanil combined with 50-150 µg/kg/min propofol will

Treatment - Drugs

Intervention group: 0.25 µg/kg/min remifentanil will be infused during operation.

Control group: 1 µg/kg/min remifentanil combined with 50-150 µg/kg/min propofol will be infused during operation.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Class I and II in American society of anesthesiology classification; aged between 18-40 years old. Exclusion criteria: Body mass index (BMI) more than 30; sensitivity to anesthesia drugs will be used in study; history of cardiac, endocrine, hepatic, renal and pulmonary diseases; chronic use of opioid drugs or alcohol.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate. Timepoint: 3 weeks after embryo transfer. Method of measurement: ultrasonography study.;Rate of transferred oocytes. Timepoint: after operation. Method of measurement: will be counted using microscope.;Number of collected oocytes. Timepoint: during operation. Method of measurement: will be counted using microscope.;Laboratory pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: B-hCG measurement.;Rate of fertilized oocytes. Timepoint: after operation. Method of measurement: will be counted using microscope.	—

Measure

Time frame

Clinical pregnancy rate. Timepoint: 3 weeks after embryo transfer. Method of measurement: ultrasonography study.;Rate of transferred oocytes. Timepoint: after operation. Method of measurement: will be counted using microscope.;Number of collected oocytes. Timepoint: during operation. Method of measurement: will be counted using microscope.;Laboratory pregnancy rate. Timepoint: 14 days after embryo transfer. Method of measurement: B-hCG measurement.;Rate of fertilized oocytes. Timepoint: after operation. Method of measurement: will be counted using microscope.

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Secondary

Measure	Time frame
Postoperative vertigo. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Postoperative hypotension. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Postoperative nausea and vomiting. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Postoperative drowsiness. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Perioperative hypotension. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative tachycardia. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative bradycardia. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative respiratory suppression. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative pain. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.	—

Measure

Time frame

Postoperative vertigo. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Postoperative hypotension. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Postoperative nausea and vomiting. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Postoperative drowsiness. Timepoint: each 5 minutes during first hour after operation. Method of measurement: physical examination.;Perioperative hypotension. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative tachycardia. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative bradycardia. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative respiratory suppression. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.;Perioperative pain. Timepoint: each 5 minutes during operation. Method of measurement: physical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Simin Atashkhoyi

Tabriz University of Medical Sciences

atashkhoii@tbzmed.ac.ir+98 41 3553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 18, 2026