fatty liver disease. nonalcoholic steatohepatitis
Conditions
Interventions
Intervention 1: silymarin, tablet 140 milligram parenteral, daily for 3 month. Intervention 2: Vitamin E,tablet 400 unit parenteral, daily for 3 month.
silymarin, tablet 140 milligram parenteral, daily for 3 month
Vitamin E,tablet 400 unit parenteral, daily for 3 month
Sponsors
Vice Chancellor for research of Yasuj University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Major inclusion criteria: Diagnosis of non-alcoholic steatohepatitis disease by sonography and elevated liver enzymes; negative history of autoimmune hepatitis, viral hepatitis, Wilson disease, hemochromatosis, a-1 antitrypsin deficiency, diabetes, hypothyroidism, cardio-pulmonary disease, kidney disease, psychiatric disease, pregnancy, alcohol consumption; also negative history for using lipid lowering drugs such as atorvastatin and gemfibrozil, estrogen, tamoxifen, corticosteroids, amiodarone, acetaminophen more than 2 grams per day, chemotherapy drugs in six months ago, anti-seizure medications such as sodium valproate, carbamazepine, phenytoin, anti-tuberculosis drugs such as isoniazid, rifampin, perazinamide. Major exclusion criteria: Patient’s displeasure to continue participation in the study; The incidence of drug-related complications.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aspartate aminotransferase. Timepoint: 3 month. Method of measurement: International Unit per Milliliter.;Alanine aminotransferase. Timepoint: 3 month. Method of measurement: International Unit per Milliliter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug reaction. Timepoint: 3 month. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMoslem Sedaghattalb
Yasuj University of Medical Science
Outcome results
None listed