Effect of vitamin D and calcium supplementation on serum levels of hormones affecting postpartum depression

Effect of vitamin D and calcium supplementation on serum levels of cortisol and inflammatory biomarkers (IL10, hsCRP) in women with postpartum depression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016111016123N12

Enrollment

Registered

2017-09-28

Start date

2017-08-28

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F53.0. Mild mental and behavioural disorders associated with the puerperium

Interventions

Intervention 1: 50000 IU pearl vitamin D3, every 14 days + 500 milligram calcium carbonate tablet, daily, for 8 weeks. Intervention 2: 50000 IU pearl vitamin D3, every 14 days + calcium carbonate plac

Treatment - Drugs

Placebo

50000 IU pearl vitamin D3, every 14 days + 500 milligram calcium carbonate tablet, daily, for 8 weeks

50000 IU pearl vitamin D3, every 14 days + calcium carbonate placebo, daily, for 8 weeks

Pearl paraffin as vitamin D placebo, every 14 days + calcium carbonate placebo, daily, for 8 weeks

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Body mass index (BMI) less than 35; age 18 to 45years; earning a score of 12 and above in Edinburgh questionnaire; period range from 1 month until 6 months after child birth. Exclusion criteria: Normal or above normal range for vitamin D levels; chronic diseases such as diabetes; renal failure; gastrointestinal diseases; liver; thyroid; kidney stones; cancer in the past 5 years; birth abnormalities; taking contraceptive drugs; endocrine disorders; severe depression and other mental disorders; using antidepressants.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Interleukin 10. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.;Cortisol. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.;HsCRP. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.	—

Secondary

Measure	Time frame
Severity of apparent (situational) and hidden (characteristic) anxiety. Timepoint: Baseline and every 14 days for 8 weeks. Method of measurement: Spill Burger Questionnaire.;Blood pressure. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Pressure gauge.;Weight. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Scales.;Serum calcium. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.;Waist Circumference. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Inflexible meter.;Depression severity. Timepoint: Baseline and every 14 days for 8 weeks. Method of measurement: Edinburgh questionnaire.;Estradiol. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.;Body Mass Index. Timepoint: Before the intervention, the end of the fourth week and and the end of the eighth week. Method of measurement: Using the formula.	—

Measure

Time frame

Severity of apparent (situational) and hidden (characteristic) anxiety. Timepoint: Baseline and every 14 days for 8 weeks. Method of measurement: Spill Burger Questionnaire.;Blood pressure. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Pressure gauge.;Weight. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Scales.;Serum calcium. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.;Waist Circumference. Timepoint: Before the intervention, end of the fourth week and end of the eighth week. Method of measurement: Inflexible meter.;Depression severity. Timepoint: Baseline and every 14 days for 8 weeks. Method of measurement: Edinburgh questionnaire.;Estradiol. Timepoint: Before and after of 8 weeks intervention. Method of measurement: Seum level.;Body Mass Index. Timepoint: Before the intervention, the end of the fourth week and and the end of the eighth week. Method of measurement: Using the formula.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSima Jafarirad

Ahvaz Jundishapur University of Medical Sciences

sjafarirad@gmail.com+98 613367543

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026