Comparison of effect of topical ophthalmic drop tacrolimus 1% versus topical ophthalmic drop dexamethasone 1% in the treatment of patients with shield ulcer

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016110630746N1

Enrollment

Registered

2016-12-25

Start date

2015-07-29

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratities. Corneal ulcer

Interventions

Intervention 1: Group 1: administration of topical ophthalmic drop tacrolimus 1% of Zahravi-Tehran company one drop every 12 houre for 3 months. Intervention 2: Group 2: administration of topical opht

Treatment - Drugs

Group 1: administration of topical ophthalmic drop tacrolimus 1% of Zahravi-Tehran company one drop every 12 houre for 3 months

Group 2: administration of topical ophthalmic drop dexamethasone 1% of Tehran-Daroupakhsh company one drop every 12 houre for 3 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: no history of any eye disease; eye trauma, eye surgery and lens usage; no use of concomitant other drugs; no usage of corticosteroids ten days before entering the study Exclusion criteria: simultaneous eye disease; eye trauma, surgery; smoking and steroid usage lens ten days before entering the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Reepithialization. Timepoint: 2 weeks, 1 month, 2 months, 3 months after intervention and 1 months after intervention deadline. Method of measurement: Physical examination by Ophthalmologist.;Shield ulcer's size. Timepoint: 2 weeks, 1 month, 2 months, 3 months after intervention and 1 months after intervention deadline. Method of measurement: Based on physical examination by slit lamp.;Corrected visual acuity. Timepoint: 2 weeks, 1 month, 2 months, 3 months after intervention and 1 months after intervention deadline. Method of measurement: Based on physical examination by snellen chart.	—

Measure

Time frame

Reepithialization. Timepoint: 2 weeks, 1 month, 2 months, 3 months after intervention and 1 months after intervention deadline. Method of measurement: Physical examination by Ophthalmologist.;Shield ulcer's size. Timepoint: 2 weeks, 1 month, 2 months, 3 months after intervention and 1 months after intervention deadline. Method of measurement: Based on physical examination by slit lamp.;Corrected visual acuity. Timepoint: 2 weeks, 1 month, 2 months, 3 months after intervention and 1 months after intervention deadline. Method of measurement: Based on physical examination by snellen chart.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNima Rastgar Rad

Zahedan University of Medical Sciences

rrnima88@yahoo.com+98 54 3322 4991

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026