Evaluation of the effect of non-surgical periodontal treatment on disease activity in patients with ankylosing spondylitis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161106030744N3

Enrollment

Registered

2023-08-21

Start date

2023-09-02

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal disease - ankylosing spondylitis. ?????? ?? ???? ???? ?? ? ?????? ??? ??????? ??? ?? ????? ??????? ????? ?? ????

Interventions

The first group: patients with AS and PD who take non-steroidal anti-inflammatory drugs (NSAID) who will receive non-surgical periodontal intervention including SRP. The second group: patients with AS

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 18 years of age or older Confirmed diagnosis of active AS by a rheumatologist Moderate to severe generalized chronic periodontitis Patients who have at least 20 teeth

Exclusion criteria

Exclusion criteria: Antibiotic use in a period of 3 months before the study Received non-surgical periodontal treatment in the last 6 months smoking Severe liver or kidney failure Uncontrolled diabetes Heart disease History of radiation therapy or chemotherapy Taking drugs with a possible effect on the periodontium (such as cyclosporine, phenytoin, calcium channel blockers) Severe dry mouth Pregnancy and breastfeeding Patients who do not return to measure the investigated variables in the sixth and twelfth weeks

Design outcomes

Primary

Measure	Time frame
Bath Ankylosing Spondylitis Disease Activity(BASDAI). Timepoint: 0_ 12 weeks after the intervention. Method of measurement: The BASDAI consists of a 0-10 scale (0 being no problem and 10 being the worst problem) that is used to answer 6 questions related to the 5 main AS symptoms.	—

Secondary

Measure	Time frame
Periodontal indices (PI, GI, PPD, GBI, CAL). Timepoint: 0_ 6 weeks after the intervention_ 12 weeks after the intervention. Method of measurement: CAL: The distance from Cej to the apical depth of the probe is in millimeters. GBI: whether probing causes bleeding (+) or not (-) is assessed. PPD: the distance from the free margin of the gingiva to the bottom of the sulcus depth in millimeters. GI: ??evaluation of the intensity and amount of gingival inflammation with BOP of the tooth. PI: It is based on the registration of soft debris and mineral deposits on the following teeth: upper right first molar, upper right lateral, upper left first premolar, lower left first molar, lower left lateral and lower right first premolar.	—

Measure

Time frame

Periodontal indices (PI, GI, PPD, GBI, CAL). Timepoint: 0_ 6 weeks after the intervention_ 12 weeks after the intervention. Method of measurement: CAL: The distance from Cej to the apical depth of the probe is in millimeters. GBI: whether probing causes bleeding (+) or not (-) is assessed. PPD: the distance from the free margin of the gingiva to the bottom of the sulcus depth in millimeters. GI: ??evaluation of the intensity and amount of gingival inflammation with BOP of the tooth. PI: It is based on the registration of soft debris and mineral deposits on the following teeth: upper right first molar, upper right lateral, upper left first premolar, lower left first molar, lower left lateral and lower right first premolar.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Elham Fakhari

Gorgan University of Medical Sciences

Dr.fakhari@goums.ac.ir+98 17 3255 0700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026