Acute hypoxemic respiratory failure. Acute respiratory failure with hypoxia
Conditions
Interventions
Intervention 1: In the ASV or intervention group,Minute Volume:100% and pressure set on 30 CmH2O to reach O2Saturation: 88-92% and PEEP = 5 and flow trigger 1-3 l / min.As the patient's condition impr
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 85 Years
Inclusion criteria
Inclusion criteria: Intubated patients with acute respiratory failure type I (hypoxemic) Endotracheal intubation and mechanical ventilation less than 48 hours Respiratory failure based on PaO2/FiO2=150-250 (P / F Ratio = 150-250)
Exclusion criteria
Exclusion criteria: Patients with acute respiratory failure and PaO2/FiO2( P / F Ratio) less than 150 Neuromuscular and diaphragmatic disorders Chest deformity Suspected Intracranial Hypertension Chronic obstructive pulmonary disease and severe asthma Chronic heart failure Chronic renal failure Refractory shock Diagnosed Barotrauma and Lung Contusion Age under 16 and over 85 years Pregnancy Abdominal compartment syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung compliance. Timepoint: Measurement of lung compliance on days 1, 2, 3 and 7 after ASV or SIMV setting. Method of measurement: compliance measurment is based on ventilator information.;Lung resistance. Timepoint: Measurement of lung resistance on days 1, 2, 3 and 7 after ASV or SIMV setting. Method of measurement: resistance measurment is based on ventilator information. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II Scoring System. Timepoint: At the time of admission. Method of measurement: According to the case report.;Oxygenation based on the ratio of arterial oxygen pressure to the Fio2. Timepoint: Days 1, 2, 3 and 7 after the start of ventilation mode. Method of measurement: Based on sample information of ABG blood gas analysis.;Arterial blood carbon dioxide pressure PaCO2. Timepoint: Days 1, 2, 3 and 7 after the start of ventilation mode. Method of measurement: Based on sample information of ABG blood gas analysis.;Fentanyl intake. Timepoint: Days 1, 2, 3 and 7 after the start of ventilation mode. Method of measurement: Based on patient record (micrograms).;Number of ventilator free days at day 28. Timepoint: Twenty-eighth day after intervention. Method of measurement: Based on patient record.;Intensive care unit length of stay. Timepoint: At the time of discharge from the intensive care unit. Method of measurement: Based on patient record.;Richmond Agitation and Sedation Scale (RASS score). Timepoint: Days 1, 2, 3 and 7 after the start of ventilation mode. Method of measurement: Based on patient record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Naseh
Tehran University of Medical Sciences
Outcome results
None listed