propranolol effect on pregnancy

A comparison between misoprostol plus propranolol and misoprostol alone in labour induction ( in post term pregnancies. )

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016110530709N1

Enrollment

Registered

2016-12-18

Start date

2016-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labour induction. Failed induction of labour

Interventions

Intervention 1: The Intervention group recieve 20mg Propranolol tablet concurrent with sublingual Misoprostol at the begining of induction. If there is no effective contraction, the dose will be repea

Treatment - Drugs

Placebo

The Intervention group recieve 20mg Propranolol tablet concurrent with sublingual Misoprostol at the begining of induction. If there is no effective contraction, the dose will be repeated after 3 hour

The Control group recieve oral Placebo tablets that their shape, color and weight are similar to 20mg propranolol tablets, in the same way of the intervention group.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: nulliparous women with Gestational age more than 41 weeks ? Single pregnancy? Cephalic presentation? Bishop score<5? indication for the induction of delivery? admitted in academic hospitals Exclusion criteria: Pregnant women with uterus contraction? fetal distress? Suspected macrosomia? Polyhydroamnius? Systolic blood pressure less than 100mmHg? Pulse rate less than 60 and more than 120? Any history of cardiopulmonary disease ?alcohol abuse.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The time of begining of effective contractions. Timepoint: Before Intervention and after effective contractions. Method of measurement: minute.	—

Secondary

Measure	Time frame
The time lapse from the beginning of induction to 4cm dilatation. Timepoint: before intervention and at the time of 4cm dilatation. Method of measurement: minute.;The time lapse from the beginning of induction to delivery. Timepoint: before intervention and at the time of delivery. Method of measurement: minute.;Neonatal Apgar score. Timepoint: At the first and the fifth minutes after birth. Method of measurement: Apgar scale.;Neonatal NICU admission. Timepoint: The first day after the birth. Method of measurement: Questionnaire.;Cesarean rate. Timepoint: Birth time. Method of measurement: Questionnaire.	—

Measure

Time frame

The time lapse from the beginning of induction to 4cm dilatation. Timepoint: before intervention and at the time of 4cm dilatation. Method of measurement: minute.;The time lapse from the beginning of induction to delivery. Timepoint: before intervention and at the time of delivery. Method of measurement: minute.;Neonatal Apgar score. Timepoint: At the first and the fifth minutes after birth. Method of measurement: Apgar scale.;Neonatal NICU admission. Timepoint: The first day after the birth. Method of measurement: Questionnaire.;Cesarean rate. Timepoint: Birth time. Method of measurement: Questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAtiyeh Mohamadzade Vatanchi

Mashhad University of Medical Sciences

vaatnchia@mums.ac.ir+98 51 3801 2477

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026