Impact of probiotic supplementation in treatment of periodontal patients with type 2 diabetes mellitus

Impact of probiotic supplementation on periodontal indices, lipid profile, inflammatory markers and Glycemic Control in periodontal patients with type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016110430694N1

Enrollment

Registered

2017-01-28

Start date

2016-11-15

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impact of probiotic supplementation on periodontal indices, lipid profile, inflammatory markers and Glycemic Control in periodontal patients with type 2 diabetes mellitus. Non-insulin-dependent diabetes mellitus, Chronic periodontitis

Interventions

Intervention 1: Intervention: The intervention group receive probiotic supplement (500 mg as capsulated) for 8 weeks. Intervention 2: control: the control group receive placebo capsules containing whe

Intervention: The intervention group receive probiotic supplement (500 mg as capsulated) for 8 weeks.

control: the control group receive placebo capsules containing wheat flour (500 mg) for 8 weeks.

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Males and females aged (30 – 60 y); type 2 diabetic patients (at least 5 years of diagnosis) with chronic periodontal disease; BMI = 18.5 < 30kg/m2 Exclusion criteria: Diabetic complications such as renal failure; using insulin therapy; pregnancy; breast feeding; traveling greater than 1 weeks; smoking; using any dietary supplements including probiotic and antioxidant supplements; using immunosuppressive medications; history of periodontal therapy; following specific diet; changing usual diet and planning to weight loss

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Fasting blood sugar. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;IL-6. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;Hb-A1c. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;Hs-CRP. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;TNF-a. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;Total cholesterol. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;HDL-C. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;LDL-C. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;TG. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;Bleeding during probe. Timepoint: Immediately Before and after the intervention. Method of measurement: Evaluation of bleeding.;Plaque index. Timepoint: Immediately Before and after the intervention. Method of measurement: Plaque is on the tooth surface.;Pocket dept. Timepoint: Immediately Before and after the intervention. Method of measurement: The probing depth is measured by the probe.;Clinical attachment level. Timepoint: Immediately Before and after the intervention. Method of measurement: Depth study of cement and enamel plaque periodontal.	—

Measure

Time frame

Fasting blood sugar. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;IL-6. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;Hb-A1c. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;Hs-CRP. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;TNF-a. Timepoint: Immediately Before and after the intervention. Method of measurement: Elisa.;Total cholesterol. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;HDL-C. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;LDL-C. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;TG. Timepoint: Immediately Before and after the intervention. Method of measurement: Using enzymatic kits.;Bleeding during probe. Timepoint: Immediately Before and after the intervention. Method of measurement: Evaluation of bleeding.;Plaque index. Timepoint: Immediately Before and after the intervention. Method of measurement: Plaque is on the tooth surface.;Pocket dept. Timepoint: Immediately Before and after the intervention. Method of measurement: The probing depth is measured by the probe.;Clinical attachment level. Timepoint: Immediately Before and after the intervention. Method of measurement: Depth study of cement and enamel plaque periodontal.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmohsen yarahmadi

Ahvaz Jundishapur University of Medical Sciences

yarahmadi14671@gmail.com+98 74 3333 1257

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026