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Effect of beta blockers on children's brain injuries

Comparing the Effect of Propranolol with Placebo on the Prognosis Improvement in Children with Traumatic Brain Injuries

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20161103030683N2
Enrollment
88
Registered
2024-05-29
Start date
2023-09-06
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain lesions. Intracranial injury

Interventions

Intervention 1: Patients in the beta-blocker treatment group received 0.5 mg per kg of propranolol orally every 12 hours from the start of hospitalization until the day of discharge. Intervention 2: C

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 15 Years

Inclusion criteria

Inclusion criteria: Children with Traumatic Brain Injuries Parental consent to participate in the study Injury Severity Scale less than 3 in chest and abdomen

Exclusion criteria

Exclusion criteria: Age over 15 years Injury Severity Scale greater than 3 in chest and abdomen Parental non-consent to participate in the study

Design outcomes

Primary

MeasureTime frame
Mortality rate. Timepoint: From the beginning to the end of the study. Method of measurement: The number of dead people divided by the total number of patients in each group.;GOSE is a measure for assessing patients' functional outcomes and their level of dependency following an injury. Timepoint: At the time of discharge, 3 and 6 months after discharge. Method of measurement: It was measured using the Glasgow Coma Scale and scoring it. Scoring: from 1 (death) to 5 (significant improvement), where higher scores indicate better outcomes and greater independence.;Length of stay in PICU. Timepoint: From the beginning to the end of the study. Method of measurement: The number of days between the admission date and the discharge date of the patient from PICU.;Length of hospital stay. Timepoint: From the beginning to the end of the study. Method of measurement: The number of days between the admission date and the discharge date of the patient from hospital.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Sadegh Masoudi

Shiraz University of Medical Sciences

Masoudi@sums.ac.ir+98 71 3230 5884

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026