Condition 1: Migraine headaches. Condition 2: Migraine headaches. Migraine without aura (common migraine) Migraine with aura (classic migraine)
Conditions
Interventions
Intervention 1: Control group:Fifty patients with migraine headaches which is aggravated during menstrual periods take Nortriptiline 0.6 milligrams / kilogram at night and Propranolol one milligrams /
Sponsors
Shahed University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Migraine headaches according to International headache society criteria At least one year history of migraine headaches At least three attacks of headaches in one month Exacerbation of headaches during menstrual periods Age between eighteen to forty-five years old
Exclusion criteria
Exclusion criteria: Use of any other drugs at the beginning of study Other types of headaches or facial pain Intolerance or allergy to drugs which are used in study Abnormal neurologic exam which is unacceptable in migraine Menstrual period shorter than five days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Headache Intensity. Timepoint: Third day after beginning of treatment with acetazolamide and fifth day of menstruation in both groups. Method of measurement: Visual Analougue Scale.;Headache duration. Timepoint: At first day before beginning of treatment and at the end of each treatment episode. Method of measurement: Mean duration of attacks in hour according to patients claims.;Headache Intensity. Timepoint: Third day after beginning of treatment and fifth day of menstruation. Method of measurement: 6 Points Behavioral Rating Scale.;Headache frequency. Timepoint: At first day before beginning of treatment and at the end of each treatment episode. Method of measurement: Number of headache attacks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Allergic drug reactions (Pruritus, Redness of skin, Urticaria). Timepoint: Instantly after alarm of the patient. Method of measurement: Observation, examination and consultation with proper specialist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSiamak Afshinmajd
Shahed University
Outcome results
None listed