Comparison of the three types of medical treatment; Topical application of Nitroglycerin plus Diltiazem Gel , Bethanechol Gel and Diltiazem Gel in healing chronic anal fissure

Effect of topical application of Nitroglycerin plus Diltiazem compared with the two methods of topical use of Bethanechol and Diltiazem in the treatment of patients with chronic anal fissure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016110130623N1

Enrollment

Registered

2017-09-13

Start date

2016-10-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic anal fissure. chronic anal fissure

Interventions

Intervention 1: Interventional group 1: Combination therapy (1% Nitroglycerine ointment plus topical 5% Diltiazem gel as separate product), TDS for eight weeks. Intervention 2: Intervention group 2: b

Treatment - Drugs

Interventional group 1: Combination therapy (1% Nitroglycerine ointment plus topical 5% Diltiazem gel as separate product), TDS for eight weeks

Intervention group 2: bethanechol , 0.1% gel, topical, TDS for eight weeks

Control group: diltiazem, 5% gel, topical, TDS for eight weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: for this study does not consider specific criteria except having acute fissures. Exclusion Criteria: pregnancy; Inflammatory bowel disease; The incidence of side effects; Leave treatment; Colon cancer

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Healing of fissure. Timepoint: Before intervention , 4 and 8 weeks after intervention. Method of measurement: Examination.	—

Secondary

Measure	Time frame
Bleeding. Timepoint: Before intervention, 4 and 8 weeks after intervention. Method of measurement: Examination and question from the patient.;Pain. Timepoint: Before intervention , 4 and 8 weeks after intervention. Method of measurement: Examination and question from the patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBaran Parhizkar

Liver & Digestive Research center,Kurdistan university of medical sciences

b.parhizkar@muk.ac.ir+98 87 3366 4645

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026