The effect of probiotics on infectious disease and DNA damage in lymphocytes of dialysis patients

The effect of probiotics on the serum level of endotoxin, the faecal levels of endotoxin and DNA damage in peripheral blood mononuclear lymphocytes of dialysis patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016103130603N1

Enrollment

Registered

2017-04-14

Start date

2017-04-21

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease. Chronic kidney disease

Interventions

Intervention 1: Intervention Group: taking probiotics capsule (4BioCap 180 mg) made by Tehran Daroo company Containing: Lactobacillus acidophilus, Bifidobacterium SPP, Streptococcus thermophilus, Lact

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: over 18 years of age, glomerular filtration rate less than 15 ml/min, having routine diets

Exclusion criteria

Exclusion criteria: infectious diseases, pregnancy (for female participants), autoimmune or immunosuppressive diseases, taking immunosuppressive drugs or antibiotics, lactose intolerance

Design outcomes

Primary

Measure	Time frame
Serum level of endotoxin. Timepoint: Before and after the intervention (6 months). Method of measurement: Limulus Amebocyte Lysate (LAL) kit.;DNA Damage of peripheral blood mononuclear lymphocytes. Timepoint: Before and after the intervention (6 months). Method of measurement: Comet Assay.;Faecel level of endotoixn. Timepoint: Before and after the intervention (6 months). Method of measurement: Limulus Amebocyte Lysate (LAL) kit.	—

Measure

Time frame

Serum level of endotoxin. Timepoint: Before and after the intervention (6 months). Method of measurement: Limulus Amebocyte Lysate (LAL) kit.;DNA Damage of peripheral blood mononuclear lymphocytes. Timepoint: Before and after the intervention (6 months). Method of measurement: Comet Assay.;Faecel level of endotoixn. Timepoint: Before and after the intervention (6 months). Method of measurement: Limulus Amebocyte Lysate (LAL) kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Jafar

Shahroud University of Medical Sciences

mani_jafar@yahoo.com+98 23 3239 5054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026