reflux. Gastro-esophageal reflux disease
Conditions
Interventions
Intervention 1: First intervention group: Combination tablets of rose and valerian, one tablet after breakfast (For 6 weeks, Manufactured by Niak Pharmaceutical), and placebo omeprazole capsules,One t
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The age of the patient is between 18 and 60 years Reflux diagnosis based on ROME IV criteria and endoscopy without specific pathological findings Symptoms began at least 6 months ago and symptoms were present at least 2 days a week for the past 3 months The patient is not infected with Helicobacter pylori. No use of antibiotics and Proton Pump Inhibitors (PPIs) in the last 1 month
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Nonsteroidal Anti-Inflammatory Drugs (NSAID) or aspirin use Underlying diseases including heart failure; kidney failure; cirrhosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heartburn. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Heaviness after Eating. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Abdominal bloating. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Discomfort after Eating. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Unusual feeling and rise of Bitter liquid in the throat. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Dysphagia. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Belch. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire.;Early satiety. Timepoint: At baseline, 2, 6 and 8 weeks after starting the intervention. Method of measurement: Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGorgan University of Medical Sciences
Gorgan University of Medical Sciences
Outcome results
None listed