Depression phase of bipolar disorder. Bipolar affective disorder, current episode mild or moderate depression
Conditions
Interventions
Treatment - Drugs
Placebo
Sponsors
Vice Chancellor for research of Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients between 18-65 years old; patients with diagnosed bipolar depression based on DSM-5 and MADRS score equal to or more than 7 exclusion criteria: patients with anxiety disorder not related to bipolar disorder; patients with mixed episodes of depression and manic or hypomanic phase; patients with severe disease; patients who administrated antidepressant agents during 1 month ago; patients who adminsitrated any antioxidant agents or supplements during 1 month ago; patients who did not administrated drug or placebo regularly at least in 80% of study duration; pregnant patients; nursing patients
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF-a. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Interleukin 6. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Interleukin 10. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Total antioxidant capacity. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Thiol groups. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Lipid peroxidation. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Mehrpooya
Hamedan University of Medical Sciences
Outcome results
None listed