Gastric cancer. Malignant neoplasm of stomach
Conditions
Interventions
Intervention 1: Intervention group receives an Isocaloric diet with low carbohydrate content. Dietary components will change weekly in order to increase MCT oil consumption. The carbohydrates are limi
Treatment - Other
Intervention group receives an Isocaloric diet with low carbohydrate content. Dietary components will change weekly in order to increase MCT oil consumption. The carbohydrates are limited to 10 to 15%
Patients in the control group are recipients of an Isocaloric standard diet with the normal dietary components based on their dietary requirements.
Sponsors
Vice chancellor of research, International Campus, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (Inclusion criteria: diagnosis of gastric adenocarcinoma; patients with ECOG performance status of 0 to 4; patients who have not been gastrectomized; blood, liver, and kidney should be functional; patients aged 18 years and older; both genders will be recruited; leucocytes count be over 3000 cell in each mm3 of blood; neutrophil count be over 1500 cubic millimeter of blood; platelets be over 1500 per each cubic millimeter of blood; total bilirubin lower than 3mg/dL; serum creatinine lower than 2mg/dL; serum potassium less than 5 mmol/L). (Exclusion criteria: Patients which live alone during the intervention without others attendance; Diabetes; patients receiving Insulin or other anabolic drugs along with intervention; pyruvate dehydrogenase complex deficiency; and inherited porphyria ; MCT oil consumption until 5 weeks before recruitment in study; Having congestive heart failure; Uncontrolled hypertension. Severe steatorrhea and diarrhea; Gastrointestinal obstruction; Patients which could not resist the intervention for any reason; Frequent incidence of hypoglycemia during first week of intervention).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carcinoembryonic antigen (CEA). Timepoint: Before and after intervention. Method of measurement: ELISA.;Ca19-9. Timepoint: Before and after intervention. Method of measurement: ELISA.;Serum ketone bodies. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;FBS. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Body Mass Index (BMI). Timepoint: Before and after intervention. Method of measurement: Formula.;Hs-CRP. Timepoint: Before and after intervention. Method of measurement: Auto analyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.;Resting energy expenditure (REE). Timepoint: Before and after intervention. Method of measurement: Gathering the produced CO2 by indirect calorimetry.;HOMA-IR. Timepoint: Before and after intervention. Method of measurement: Is calculated by the formula.;Serum Lactate. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.;CBC-diff. Timepoint: Before and after intervention. Method of measurement: Complete blood count and differential.;Serum Albumin. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.;Karnofsky score. Timepoint: Before and after intervention. Method of measurement: Observation.;Eastern Cooperative Oncology Group (ECOG). Timepoint: Before and after intervention. Method of measurement: Observation.;Bioelectric Impedance Analysis (BIA). Timepoint: Before and after intervention. Method of measurement: Weight. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Dadfarma
School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences
Outcome results
None listed