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Effects of intravenous ceftriaxone in neurologic outcome of acute spinalcord injury patients compared with methylprednixolone alone

Effects of intravenous ceftriaxone in neurologic outcome of acute spinalcord injury patients compared with methylprednixolone alone

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016102713947N5
Enrollment
60
Registered
2017-02-11
Start date
2016-12-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Injury. Other injury of lumbar spinal cord

Interventions

Intervention 1: Case group will receivebolus infusion of methylprednisolon 33 mg/kg in 15 minutes intravenous and after 45 minutes they will receive 4,5 mg/kg infusion of methylprednisolon for 23-42 h
Treatment - Drugs
Case group will receivebolus infusion of methylprednisolon 33 mg/kg in 15 minutes intravenous and after 45 minutes they will receive 4,5 mg/kg infusion of methylprednisolon for 23-42 hours and 2 g cef
control group will receive bolus infusion of methylprednisolon 33 mg/kg in 15 minutes intravenous and after 45 minutes they will receive 4,5 mg/kg infusion of methylprednisolon for 23-42 hours.

Sponsors

Road traffic injury prevention research center, Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Patients with spinal cord injury from T10 to L2; Patients with age of 17 to 60 ; Frankle grade A to D Exclusion criteria: Patients older or younger than 17-60; Patients with head trauma and GCS score lower than 13; Reaction to Ceftriaxone use; Amp Calcium intake or other drugs with calcium ; First trimester; E grade based on Frankel classification at admission; Spinal cord injury out of T10 to L2

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Investigation of Neurological status based on Frankel Grade. Timepoint: At admission and 6 month period after admission. Method of measurement: Based on Frankel grade.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Meshkini

Department of Neurosurgery, Tabriz University of Medical Sciences

meshkinia@yahoo.com+98 41 3337 6953

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026