Diabetic Neuropathy. Diabetic polyneuropathy
Conditions
Interventions
Intervention 1: Capers extract (200mg as capsules, three times daily) as well as topical capers extract twice daily on feet for 30 days. Intervention 2: Placebo with similar dosage and form to the fir
Treatment - Drugs
Placebo
Capers extract (200mg as capsules, three times daily) as well as topical capers extract twice daily on feet for 30 days
Placebo with similar dosage and form to the first group for 30 days
Sponsors
Vice Chancellor for Research of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 18 to 65 years, diabetes mellitus type II, diabetic peripheral neuropathy. Exclusion criteria: other types of neuropathy, pregnancy and lactation, foot ulcer or amputation, consumption of antidepressants, anticonvulsants or other analgesics.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of neuropathy. Timepoint: Before and one month after intervention. Method of measurement: Michigan Neuropathy Screening Instrument (MNSI) And Neuropathy Total Symptom Score -6 (NTSS-6).;Neuropathic pain. Timepoint: Before and one month after intervention. Method of measurement: Visual Analog Scale for Pain.;Paresthesia. Timepoint: Before and one month after intervention. Method of measurement: Visual Analog Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood sugar. Timepoint: Before and one month after intervention. Method of measurement: Glucose oxidase method.;Blood lipids (triglyceride and cholesterol). Timepoint: Before and one month after intervention. Method of measurement: Blood biochemical tests by using colorimetric method.;Renal Function Tests (Blood Urea Nitrogen (BUN), creatinine). Timepoint: Before and one month after intervention. Method of measurement: Blood biochemical tests by using colorimetric method.;Liver enzymes tests: Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP). Timepoint: Before and one month after intervention. Method of measurement: Blood biochemical tests by using colorimetric method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Hamid Reza Esmaeilpour
Mashhad University of Medical Sciences, Faculty of Traditional and Complementary Medicine
Outcome results
None listed