Synergistic effects of N-acetylcysteine combined with common psychological of patients with cannabis use disorder

Synergistic effects of N-acetylcysteine combined with common psychological interventions on retention in treating and craving reduction, and its effect on quantitative electroencephalographic(QEEG) indices of patients with cannabis use disorder

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161026030510N5

Enrollment

Registered

2023-01-07

Start date

2023-02-18

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with cannabis use disorder. Cannabis abuse with intoxication

Interventions

Intervention 1: Intervention group: In this group, 20 patients will receive N-acetylcysteine medicine along with psychotherapy during 12 weeks. The drug will be daily with a dose of 1200 mg twice a da

Eligibility

Sex/Gender

Male

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Having the criteria for cannabis abuse based on DSM-5 Being between the ages of 18 and 30 years

Exclusion criteria

Exclusion criteria: Having a history of brain damage (epilepsy, convulsions, trauma, etc) Having other underlying medical diseases such as neurological disorders, etc History of severe psychiatric comorbidity (including schizophrenia, bipolar disorder, and psychotic disorders) Concomitant use of psychiatric drugs Concomitant use of drugs abuse other than smoking

Design outcomes

Primary

Measure	Time frame
Craving Score in Craving questionnaire. Timepoint: Before the start of the intervention and 12 weeks after the intervention. Method of measurement: MCQ-SF: marijuana craving questionnaire-shor form.;Retention in treating. Timepoint: Weekly. Method of measurement: Urine test.;Quantitative electroencephalographic indice. Timepoint: Before the start of the intervention and 12 weeks after the intervention. Method of measurement: EEG machine.	—

Measure

Time frame

Craving Score in Craving questionnaire. Timepoint: Before the start of the intervention and 12 weeks after the intervention. Method of measurement: MCQ-SF: marijuana craving questionnaire-shor form.;Retention in treating. Timepoint: Weekly. Method of measurement: Urine test.;Quantitative electroencephalographic indice. Timepoint: Before the start of the intervention and 12 weeks after the intervention. Method of measurement: EEG machine.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNeda Vahed

Iran University of Medical Sciences

vahedneda@yahoo.com+98 914 614 7821

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026