Effect of endoscopic vantris injection in comparison with before treatment in children with primary vesicoureteral reflux

Effect of endoscopic vantris injection in comparison with before treatment in children with primary vesicoureteral reflux: a before-after clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201610259014N126

Enrollment

Registered

2016-10-30

Start date

2015-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vesicoureteral reflux. Vesicoureteral-reflux-associated uropathy

Interventions

Intervention 1: Control group: In comparison with before intervention. Intervention 2: Intervention group: Endoscopic vantris injection 1 ml submucosal in ureter once.

Treatment - Surgery

Control group: In comparison with before intervention.

Intervention group: Endoscopic vantris injection 1 ml submucosal in ureter once.

Eligibility

Sex/Gender

All

Age

1 Years to 8 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age of 1 to 8 years; vesicoureteral reflux with grade one to three; new scar in renal parenchyma; unsuccessful medical treatment; repeated urinary tract infection. Exclusion criteria: Previous history of vantris injection; previous surgery of vesicoureteral reflux; nourogenis bladder; urinary abnormality such as uretrocell, complete duplicate system, ectopic ureter or bladder diverticulitis.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Measuring grade of reflux. Timepoint: before treatment and 3 and 6 month after treatment. Method of measurement: using nuclear scan.;Assessing recurrence of reflux. Timepoint: one year after intervention. Method of measurement: using nuclear scan.	—

Secondary

Measure	Time frame
Assessing infection. Timepoint: one month after surgery. Method of measurement: using urine culture.;Assessing hematuria. Timepoint: one month after surgery. Method of measurement: using urine analysis.;Measuring duration of hospitalization. Timepoint: after intervention. Method of measurement: through checking medical record.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Naser Shams

Shahid Beheshti Hospital

n9shams @ gmail.com+98 81 3838 0283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026