stroke. stroke, not specified as haemorrhage or infarction
Conditions
Interventions
Intervention 1: control group: conventional rehabilitation (electrical stimulation of paretic limbs, combined functional patterns of affected upper limb, gentle stretch of hypertone muscle, balance ex
Rehabilitation
control group: conventional rehabilitation (electrical stimulation of paretic limbs, combined functional patterns of affected upper limb, gentle stretch of hypertone muscle, balance exercise, gait tra
intervention group: conventional rehabilitation (electrical stimulation of paretic limbs, combined functional patterns of affected upper limb, gentle stretch of hypertone muscle, balance exercise, gai
Sponsors
Vice Chancellor of Research, Shiraz University of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: First-ever stroke resulting in right or left upper limb paresis and stroke had occurred between 2 weeks and 3 months; CT or MRI documenting a monohemispheric lesion as determined by a neurologist; Age between 18 and 80 years old; Patients with right-hand dominant according to Edingburg handedness scale; Patients with severe motor deficit of wrist extensor (score of 2 or less in strength test scale); Patients with severe to moderate motor impairment of affected upper limb (points less than 45 in items related to upper limb motor function); Not taking anti-spasticity drugs. Exclusion criteria: Other neurological diseases; Presence of pain, fracture, surgical history and joint dislocation of upper extremity; Contraindications to transcranial magnetic stimulation (TMS) including cardiac pacemaker, metal implants in skulls or eye, past history of seizure ; Presence of dementia, severe cognitive impairment (score of less than 24 points on the mini-mental status examination), aphasia and depression that made the patient uncooperative; Current use of drugs that could affect the excitability of the motor cortex, such as anti-epileptic and psychoactive drugs.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rest motor threshold. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Active motor threshold. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Recruitment curve. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Cortical silent period. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Ipsilateral silent period. Timepoint: before intervention, after intervention. Method of measurement: TMS device. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measuring performance in activities of daily living. Timepoint: before intervention, after intervention. Method of measurement: Modified Barthel Index.;Spasticity. Timepoint: before intervention, after intervention. Method of measurement: modified modified ashworth scale.;Wrist extensor muscle strength. Timepoint: before intervention, after intervention. Method of measurement: isokinetic dynamometer biodex device.;Assessment of motor function. Timepoint: before intervention, after intervention. Method of measurement: Fugl-Meyer Assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasrin Salehi Dehno
Shiraz University of Medical Sciences
Outcome results
None listed