The Effect of Exercise and Diet on Fatty Liver Disease

The Effect of Eight Weeks Endurance Training and Low Calorie Diet on Serum Levels of Some Biomarkers Related to Endothelial Dysfunction-Atherosclerosis and Carotid Artery Carotid Intima Media Thickness in Men Involved Non-alcoholic Fatty Liver Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016102330450N1

Enrollment

Registered

2017-03-03

Start date

2016-11-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic Fatty Liver Disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Endurance Exercise. Intervention 2: Endurance Exercise with Diet. Intervention 3: Diet. Intervention 4: Control Gruop, Without Lifestyle Modality.

Lifestyle

Endurance Exercise

Endurance Exercise with Diet

Control Gruop, Without Lifestyle Modality

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Men with nonalcoholic fatty liver grade 2 and 3 detected by ultrasound; Do not use alcohol; Aged 18 to 45 years; The ability of doing physical exercise. Exclusion criteria: Use of drug-induced hepatic steatosis such as prednisone, corticosterone, amiodarone and ...; uses more from 20 grams of alcohol daily; Hepatitis B and C.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Visfatin. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Resistin. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Hs-CRP. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Lipid Profile. Timepoint: Before & aeter 8 weeks modality. Method of measurement: LDL,HDL.Chol,TG,VLDL.;Homocysteine. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Chemerin. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Carotid Intima Media Thickness. Timepoint: Before and aete 8 weeks modality. Method of measurement: Ultrasound.;Pentraxin-3. Timepoint: Before and aete 8 weeks. Method of measurement: ELISA.	—

Measure

Time frame

Visfatin. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Resistin. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Hs-CRP. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Lipid Profile. Timepoint: Before & aeter 8 weeks modality. Method of measurement: LDL,HDL.Chol,TG,VLDL.;Homocysteine. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Chemerin. Timepoint: Before & aeter 8 weeks modality. Method of measurement: ELISA.;Carotid Intima Media Thickness. Timepoint: Before and aete 8 weeks modality. Method of measurement: Ultrasound.;Pentraxin-3. Timepoint: Before and aete 8 weeks. Method of measurement: ELISA.

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Secondary

Measure	Time frame
ALT. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;AST. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Body Mass Index. Timepoint: Before & after 8 weeks. Method of measurement: Weight and Height.;Malondialdehyde. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Superoxide Dismutase. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Glutathione Peroxidase. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Total Antioxidant Capacity. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.	—

Measure

Time frame

ALT. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;AST. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Body Mass Index. Timepoint: Before & after 8 weeks. Method of measurement: Weight and Height.;Malondialdehyde. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Superoxide Dismutase. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Glutathione Peroxidase. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.;Total Antioxidant Capacity. Timepoint: Before & after 8 weeks. Method of measurement: ELISA.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAsghar Mahmoudi

University of Mohaghegh Ardabili

asgharmahmoodi64@yahoo.com+98 45 3352 3164

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026