Curcumin and/or omega-3 polyunsaturated fatty acids supplementation in diabetes mellitus

Investgation of the effect of Curcumin and/or omega-3 polyunsaturated fatty acids supplementation on anthropometric indices, glucose hemostasis, markers of cardiometabolic risk and gene expression of vascular endothelial growth factor and serum concentrations of inflammatory and oxidatve stress indices in type 2 diabetic patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161022030424N5

Enrollment

100

Registered

2019-12-02

Start date

2019-12-22

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group 1: Daily intake of two 1000 mg omega-3 capsules (Zahravi pharma co.) and two 500 mg turmeric capsules (made by Dineh Company) for 12 weeks after meals. Intervention

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: > 18 years old Diagnosed as having T2DM based on the criterion of the American Diabetes Association At least moderately controlled diabetes (%5/8>HbA1c) A stable anti-diabetic drug regimen (over 4 months) before starting the study

Exclusion criteria

Exclusion criteria: Omega 3 fatty acids supplement intake Multivitamin-mineral supplements or medicinal products that interfere with patients' lipid profile Cancer and any chronic disease other than diabetes Pregnancy and lactation Smoking Drinking

Design outcomes

Primary

Measure	Time frame
Anthropometric indices. Timepoint: Measurement of body weight at baseline (before intervention) and 6 and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Seca digital scale.;Glucose homeostasis (fasting glucose and insulin concentration). Timepoint: Measurement of glucose homeostasis at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.;Cardiometabolic risk markers (triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol and VLDL cholesterol). Timepoint: Measurement of cardiometabolic risk markers at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.;Gene expression of vascular endothelial growth factor. Timepoint: Measurement of Gene expression of vascular endothelial growth factor at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.	—

Measure

Time frame

Anthropometric indices. Timepoint: Measurement of body weight at baseline (before intervention) and 6 and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Seca digital scale.;Glucose homeostasis (fasting glucose and insulin concentration). Timepoint: Measurement of glucose homeostasis at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.;Cardiometabolic risk markers (triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol and VLDL cholesterol). Timepoint: Measurement of cardiometabolic risk markers at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.;Gene expression of vascular endothelial growth factor. Timepoint: Measurement of Gene expression of vascular endothelial growth factor at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.

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Secondary

Measure	Time frame
Serum concentration of inflammatory indices (hs-CRP). Timepoint: Measurement the serum levels of inflammatory markers at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.;Serum concentration of oxidative stress indices (MDA and TAC). Timepoint: Measurement the serum levels of oxidative stress indices at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.	—

Measure

Time frame

Serum concentration of inflammatory indices (hs-CRP). Timepoint: Measurement the serum levels of inflammatory markers at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.;Serum concentration of oxidative stress indices (MDA and TAC). Timepoint: Measurement the serum levels of oxidative stress indices at baseline (before intervention) and 12 weeks after omega-3 and / or turmeric supplementation. Method of measurement: Biochemical analysis.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNeda Dolatkhah

Tabriz University of Medical Sciences

neda_dolatkhah@yahoo.com0984133361928

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026