Knee osteoarthritis. Primary gonarthrosis, bilateral
Conditions
Interventions
Intervention 1: Intervention group: 5:2 fasting diet with high-protein intermittent content for 4 months (This diet involves maintaining normal eating habits for five consecutive days a week, maintain
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diagnosis of knee osteoarthritis by a physical medicine specialist Stopping menstrual cycle naturally 12 months ago Body mass index of 25 kg/m2 and above Not having another inflammatory disease such as rheumatoid arthritis No intra-articular injection for the past 3 months No oral medication (nonsteroidal anti-inflammatory drugs) for one week prior to study entry.
Exclusion criteria
Exclusion criteria: Daily calorie intake of less than 800 and more than 4200 kcal A deviation from a specific eating pattern due to medical or other reasons Use of dietary supplements, diuretics, or laxatives during the intervention period Participation in sports programs or changes in physical activity Failure to follow the recommended diet Use of weight-affecting medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Weight measurement at the beginning of the study (before the start of the intervention) and 1, 2, 3 and 4 months after the start of the intervention. Method of measurement: Seca digital scale.;Body mass index. Timepoint: Body mass index measurement at the beginning of the study (before the start of the intervention) and 1, 2, 3 and 4 months after the start of the intervention. Method of measurement: Calculation.;Body fat mass. Timepoint: Measurement of body fat mass at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Body analyzer.;Fat-free body mass. Timepoint: Measurement of fat-free body mass at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Body analyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: Pain intensity measurement at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Visual Analogue Scale.;Functional status. Timepoint: Measurement of functional status at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC).;High-sensitivity C-reactive protein (hsCRP) level. Timepoint: Measurement of high-sensitivity C-reactive protein (hsCRP) levels at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Biochemical analysis.;Total antioxidant capacity (TAC) level. Timepoint: Measurement of total antioxidant capacity (TAC) levels at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Biochemical analysis.;Malondialdehyde (MDA) level. Timepoint: Measurement of Malondialdehyde (MDA) levels at the beginning of the study (before the start of the intervention) and 4 months after the start of the intervention. Method of measurement: Biochemical analysis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNeda Dolatkhah
Tabriz University of Medical Sciences
Outcome results
None listed