The effect of Linum usitatissimum L. (flax seed) oil along with a calorie restricted diet in patients with knee osteoarthritis

The effect of oral administration and topical application of Linum usitatissimum L. (flax seed) oil along with a calorie restricted diet on anthropometric indices, pain, physical function, and serum indices of oxidative stress in patients with knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161022030424N10

Enrollment

Registered

2023-12-29

Start date

2024-04-18

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: The first intervention group: was given one flax seed oil (Barij Essential Oil Company, Kashan, Iran) three times a day for 8 weeks, plus topical flax seed oil (Barij Essential Oil Com

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnosis of knee osteoarthritis by a physical medicine specialist (mild, moderate) based on the diagnostic criteria of the American College of Rheumatology and the radiological evaluation of knee osteoarthritis by Clairgen Lawrence Overweight and obese people based on body mass index of 25-40 weight per square meter Not taking anticoagulants Absence of knee joint replacement surgery Absence of fractures involving the surface of the knee joint Absence of skin diseases in the knee area Absence of other systemic rheumatic diseases or RA, neuropathy, sensory disturbances due to drug, sedative or tobacco use

Exclusion criteria

Exclusion criteria: Treatment with oral or intra articular corticosteroids in the past 3 months

Design outcomes

Primary

Measure	Time frame
Physical performance. Timepoint: Evaluation of physical performance at baseline (before intervention) and 8 weeks after starting the oral and topical supplement of flaxseed oil. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire.	—

Secondary

Measure	Time frame
Pain intensity. Timepoint: Measurement of the pain intensity at baseline (before intervention) and 8 weeks after oral and topical supplement of flaxseed oil. Method of measurement: Visual Analogue Scale.;Anthropometric indices. Timepoint: Measurement of the anthropometric indices at baseline (before intervention) and 8 weeks after oral and topical supplement of flaxseed oil. Method of measurement: Seca digital scale.;Serum concentration of oxidative stress indices (MDA and TAC). Timepoint: Measurement of the serum levels of inflammatory markers at baseline (before intervention) and 8 weeks after oral and topical supplement of flaxseed oil. Method of measurement: Biochemical analysis.	—

Measure

Time frame

Pain intensity. Timepoint: Measurement of the pain intensity at baseline (before intervention) and 8 weeks after oral and topical supplement of flaxseed oil. Method of measurement: Visual Analogue Scale.;Anthropometric indices. Timepoint: Measurement of the anthropometric indices at baseline (before intervention) and 8 weeks after oral and topical supplement of flaxseed oil. Method of measurement: Seca digital scale.;Serum concentration of oxidative stress indices (MDA and TAC). Timepoint: Measurement of the serum levels of inflammatory markers at baseline (before intervention) and 8 weeks after oral and topical supplement of flaxseed oil. Method of measurement: Biochemical analysis.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNeda Dolatkhah

Tabriz University of Medical Sciences

neda_dolatkhah@yahoo.com+98 41 3336 1928

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026