Multiple Sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: Probiotic capsule containing 250 mg yeast of Saccharomyces bullaria (1010 CFU) and 100 mg of magnesium and lactose stearates daily after a meal, for 4 months manu
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Having a disease for more than a year Multiple sclerosis confirmed by a neurologist No other chronic diseases Lack of mental illness Not pregnant Not consuming probiotic foods from a month before the study
Exclusion criteria
Exclusion criteria: Unwillingness to continue studying at each stage Consumption of any probiotic food during the study Acute gastrointestinal disease Antibiotic use during the study Acute and severe phase of MS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mental health. Timepoint: Determining mental health at the beginning of the study (before the intervention) and 2 and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: General Health Questionnaire (GHQ-28).;Quality of life. Timepoint: Determining quality of life at the beginning of the study (before the intervention) and 2 and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: SF-36 quality of life questionnaire.;Pain. Timepoint: Determining pain at the beginning of the study (before the intervention) and 2 and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: visual analogue scale.;Fatigue. Timepoint: Determining fatigue at the beginning of the study (before the intervention) and 2 and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: fatigue severity scale (FSS).;Hs-CRP inflammatory index. Timepoint: Determining hs-CRP inflammatory index at the beginning of the study (before the intervention) and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: biochemical assay.;Total antioxidant capacity (TAC). Timepoint: Determining total antioxidant capacity (TAC) at the beginning of the study (before the intervention) and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: biochemical assay.;Superoxide dismutase (SOD). Timepoint: Determining superoxide dismutase (SOD) at the beginning of the study (before the intervention) and 4 months after starting the administration of probiotic or placebo supplementation. Method of measurement: biochemical assay.;Malondialdehyde (MDA). Timepoint: Determining malondialdehyde (MDA) at the beginning of the study (before the intervention) and 4 months after starting the administration of probiotic or placeb | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNeda Dolatkhah
Tabriz University of Medical Sciences
Outcome results
None listed