Catheter related blood stream infection. Catheter-related bloodstream infection (CRBSI)
Conditions
Interventions
Patient on hemodialysis (regimen 2/2/3) with suspected CRBSI will be treated with Daptomycin at 10mg/kg immediately after dialysis (2 minutes intravenous infusion). Area under curve for 48h (AUC48h),
Treatment - Drugs
Sponsors
CHU de Poitiers
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion: patients > 18 years, requiring conventional hemodialysis for chronic renal failure hospitalized at the University Hospital of Poitiers (CHU de Poitiers) and presenting a CRBSI. Exclusion: pregnant or breeding women, pneumonia, septic shock (which may affect pharmacokinetic parameters and therefore not represent the principal hemodialysis population); CPK >3ULN; known hypersensitivity to Daptomycin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetics of Daptomycin at 10 mg/kg after dialysisin conventional hemodialysis in patients with central catheter related infections. Timepoint: 1 week. Method of measurement: Cmax, Cmin, AUC. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate clinical parameters (physical examination, vital signs and temperature) in order to monitor infection evolution and side effects in relation to Daptomycin treatment. Timepoint: 2 weeks. Method of measurement: Cinical examination. | — |
Countries
France
Contacts
Public ContactGuillaume Béraud
CHU de Poitiers
Outcome results
None listed