obesity. Obesity, Localized adiposity
Conditions
Interventions
Intervention 1: Intervention1: Daily intake of 2 g Spirulina as 4 tablets of 5oo mg for 3 months, weight reduction diet therapy simultaneously with Spirulina supplements for 12 weeks. Intervention 2:
Treatment - Drugs
Placebo
Intervention1: Daily intake of 2 g Spirulina as 4 tablets of 5oo mg for 3 months, weight reduction diet therapy simultaneously with Spirulina supplements for 12 weeks
Intervention 2: Daily intake of 4 placebo tablets for 12 weeks, weight reduction diet therapy concurrently with receiving placebo for 12 weeks
Sponsors
Vice chancellor for research, Shahid Beheshti University of Medical Sciences
Ashbal Chemi Co.
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: aged 20-60 years old, 40 kg/m2 >BMI>25 kg/m2, no history of medications for obesity, diabetes, dyslipidemia, inflammatory diseases and vitamin supplementation within 3 months before the study Exclusion criteria: having chronic kidney or hepatic disease except NAFLD, hypo or hyperthyroidism, autoimmune and infectious disease, weight reduction diet therapy within 6 month, more than 3 kg weight change in recent 2 months and recent surgery, taking anticoagulant medications the same as warfarin or aspirin, pregnancy and lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: seca scale.;BMI. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: calculation (kg/m2).;Waist circumference. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: metere.;Hip circumference. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: metere.;Waist/hip. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: calculation.;Body fat mass. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: Bioelectrical impedance analysis (BIA) device.;Body fat free mass. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: Bioelectrical impedance analysis (BIA) device.;Appetite. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: simple appetite questionnaire.;Serum adiponectin. Timepoint: Before intervention and after 12 weeks of intervention. Method of measurement: ELISA.;Serum hs-CRP. Timepoint: Before intervention and after 12 weeks of intervention. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum triacylglycerol. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun).;Serum total cholesterol. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun).;HDL-C. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun).;LDL-C. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun).;LDL-C/HDL-C. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: calculation.;Srum glucose. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun).;Serum insulin. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: ELISA.;HOMA-IR. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: calculation ([Glucose]*[Insulin]/405(Glucose in mg/dl)).;Serum SGOT. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun).;Serum SGPT. Timepoint: before intervention and after 12 weeks of intervention. Method of measurement: Colorimetric enzymatic method (Pars Azmun). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRehaneh Yousefi
National Institute of Nutrition and Food Technology
Outcome results
None listed