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Comparison of the effect of botanical extract mouthwashes of meswak/aloe vera and chlorhexidine on prevention of ventilator-associated pneumonia

Comparison of the effect of botanical extract mouthwashes of meswak/aloe vera and chlorhexidine on prevention of ventilator-associated pneumonia in ventilated patient

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20161014030294N4
Enrollment
70
Registered
2020-09-09
Start date
2020-06-20
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated pneumonia.

Interventions

Intervention 1: Intervention group: Mouthwash containing toothbrush wood extract / Aloe vera produced by Barij Essential Oil Company is used. 5 ml of mouthwash is poured into different parts of the mo

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Existence of endotracheal tube through the mouth Age 16 to 65 years Mechanical ventilation for at least 72 hours Absence of lung infection based on the clinical score of the modified lung infection Lack of sensitivity to plant compounds Absence of sepsis Absence of pulmonary thromboembolism Absence of atelectasis Absence of inflammatory diseases of the gastrointestinal tract Absence of severe liver and bile duct diseases

Exclusion criteria

Exclusion criteria: Transfer the patient from the ICU or die before completing the study Reluctance of the patient's companions to continue the study Observe the side effects of using mouthwash such as hives, itching and skin rashes Sudden changes in the patient's clinical condition or respiratory pattern occur Existence of defects in the patient's immune system

Design outcomes

Primary

MeasureTime frame
The rate of ventilator-induced pneumonia. Timepoint: 72 hours and 7 days after the intervention and when the patient is extubated. Method of measurement: Microbiological tests of lung secretions.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMansoreh Karimi Kia

Arak University of Medical Sciences

karimikia93@gmail.com+98 86 3313 6055

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026