Valvular heart disease. Nonrheumatic mitral valve disorders, Nonrheumatic aortic valve disorders, Nonrheumatic tricuspid valve disorders, Pulmonary valve disorders
Conditions
Interventions
Intervention 1: During open heart surgery when patient is on cardiopulmonary bypass after aortic cross clamping and cardioplegic arrest patients undergoing pulsatile perfusion.
pulsatile features on h
During open heart surgery when patient is on cardiopulmonary bypass after aortic cross clamping and cardioplegic arrest patients undergoing pulsatile perfusion.
pulsatile features on heart lung machi
In control group during cardiopulmonary bypass after aortic cross clamping patients undergoing routine(non pulsatile) perfusion.
Sponsors
Vice Chancellor Of Research, Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with valvular heart disease that needs surgical replacement or repair of heart valves, body surface area less than 2, Age 18 to 65, Estimated cardiopulmonary bypass time greater than 60 minute, Left ventricle ejection fraction(LVEF) 40% and greater than 40% Exclusion criteria: patients with carotid stenosis, atherosclerosis of ascending aorta and aortic arch, history of cerebrovascular accident, diabetic patient, hepatic disorders, alcoholism, patients needs emergency or complicated and redo surgeries, congenital heart disease, pregnancy, patients disagreement(without consent), preoperation arterial lactate levels greater than 2 miliigram per deciliter, arteial blood gases not in normal rang during cardiopulmonary bypass, patients who needs intraaortic baloon pump(IABP), extracorporeal membrane oxygenation(ECMO) or patients with open sternum, cardiac arrest
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood lactate level. Timepoint: after anasthasia and mechanical ventilation, after aortic cross clamping, after aortic cross clamp removal, termination of cardiopulmonary bypass, 2 and 4 hours post operation room. Method of measurement: arterial blood sample ( our lab reference unit is milligram per decilitre).;Cerebral oxygenetion. Timepoint: During the whole time of surgery and cardiopulmonary bypass. Method of measurement: To evaluate cerebral oxygenetion we use INVOS cerebral /somatic oxymeter, the values are measured continuously as a percentage of oxygen saturation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver enzymes(AST& ALT). Timepoint: Pre & Post operation. Method of measurement: blood sample(our lab reference unit is Unit per liter).;Renal function tests( BUN & Cr). Timepoint: Pre & Post operation. Method of measurement: blood sample(our lab reference unit is milligram per deciliter).;Lactate dehydrogenase(LDH). Timepoint: Pre & Post operation. Method of measurement: blood sample( our lab reference unit is Unit per liter).;Platelet count. Timepoint: Pre & Post operation. Method of measurement: blood sample(our lab reference unit is platelete count per microliters).;Urine out put. Timepoint: Pre CPB, Pre aortic cross clamp, after removal of aortic cross clamp, termination of CPB. Method of measurement: Through direct vision urine volume(in millilite)r is measured by collecting in urine bag. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSamira Moosaei Far
Iran University of Medical Sciences
Outcome results
None listed