The effectiveness of oral Tizanidine on duration of sensory block in patients undergoing surgery

A clinical trial to comparison the effectiveness of oral Tizanidine and placebo on duration of sensory block and hemodynamic changes in patients undergoing limb orthopedic surgery under spinal anesthesia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201610104780N10

Enrollment

Registered

2016-10-21

Start date

2016-10-31

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic surgery under spinal anesthesia. -

Interventions

Intervention 1: Control group: they will recieve 4 mg of placebo, 90 minutes before spinal anesthesia. Intervention 2: Intervention group: they will recieve 4 mg of oral Tizanidine 90 minutes before s

Treatment - Drugs

Control group: they will recieve 4 mg of placebo, 90 minutes before spinal anesthesia.

Intervention group: they will recieve 4 mg of oral Tizanidine 90 minutes before spinal anesthesia.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Aged between 18 and 60 years; ASA I or II scheduled for limb orthopedic surgery under spinal anesthesia. Exclusion criteria: History of high blood pressure; history of uncontrolled diabetes; history of cardiovascular disease; history of renal failure; history of cirrhosis; history of smoking or drug abuse; patients with paresthesia level higher than T4.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Duration of sensory block. Timepoint: Each 15 minutes after spinal anesthesia. Method of measurement: Pin prick method.	—

Secondary

Measure	Time frame
Blood pressure and heart rate. Timepoint: Before and 5, 10, 15, 30, 60 and 90 minutes after spinal anesthesia. Method of measurement: Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Alipour

Mashhad University of Medical Sciences

alipourm@mums.ac.ir+98 51 3728 1401

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026