Nephrotoxicity. Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
Conditions
Interventions
Intervention 1: Intervention group: Includes 20 patients who received 500 ml of normal saline before injection of amphotericin and 1.5 vial sodium bicarbonate vial in 500 cc dextrose water, equivalent
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 15 years Receive amphotericin for at least 7 days No history of kidney disease (including chronic kidney disease) and hemodialysis Signing up the informed consent form
Exclusion criteria
Exclusion criteria: Heart failure class 3 and 4 Known liver failure Known acute or chronic kidney disease Alkalosis (pH greater than 7.5 or sodium bicarbonate plasma greater than 30 meq / lit) Symptomatic hypocalcemia, hypokalemia or hypomagnesemia Sensitivity and any adverse effect that occurred after the injection of bicarbonate in the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amphotericin b nephrotoxicity defined by either doubling of Scr from the baseline value or =50 % decrease in GFR. Timepoint: SCr and GFR are measured every other day during the intervention (Days 1, 3, 5 & 7). Method of measurement: Measurement of serum creatinine using an autoanalyzer device.;Electrolyte disorders including hypokalemia (serum level potassium below 3 mEq/L) and hypomagnesemia (serum magnesium level below 1.2 mEq/L). Timepoint: Serum potassium and magnesium levels are determined in the first and last days of the intervention (Days 1 & 7). Method of measurement: Measurement of serum electrolytes using an autoanalyzer device. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactIman Karimzadeh
Shiraz University of Medical Sciences
Outcome results
None listed