Gentamicin-induced renal toxicity in hospitalized patients. Other bacterial diseases
Conditions
Interventions
Intervention 1: Intervention group: In this group, as long as the gentamicin is prescribed, the tablet of silymarin is prescribed by the Goldaru company (Livergol) at an oral dose of 140 mg three tim
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patient's hemodynamic stability The desire to participate in the study Gentamicin is given intravenous or intramuscular for at least 1 week at a dose of 5 mg / kg / day or 80-100 mg / TDS No history of confirmed acute kidney injury. No history of confirmed chronic kidney injury. No use of gentamicin by intravenous or muscle in the past 14 days. No history of confirmed allergic reactions following oral administration of silymarin No history of confirmed allergic reactions following oral administration of silymarin Do not receive medications or antioxidant compounds such as vitamin C, vitamin E or vitamin A Do not receive high-renal toxicity medicines at the same time Oral tolerance to medications
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the efficacy of silymarin in preventing renal toxicity due to gentamicin by measuring the malondialdehyde indicator, evaluation of thiol groups, isoprostane and deoxy guanosine, serum creatinine level, serum urea nitrogen, sodium, potassium and magnesium concentration, and calculating sodium, potassium, Magnesium and urea. Timepoint: Sampling from urine and blood (5 ml) of patients before starting the drug (day zero) and on days 1, 2, 3, 5 and 7, treatment with gentamicin. Method of measurement: Measurement of serum and urine levels of electrolytes, urea and creatinine using an autoanalyzer and Isoprostane and desoxy Guanosine indicator will be performed using ELISA and Zell bio kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactIman Karimzadeh
Shiraz University of Medical Sciences
Outcome results
None listed