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Use of vaginal misoprostol with and without letrozole and combination of misoprostol and laminaria for preoperative cervical ripening

Comparison of vaginal misoprostol, combination of vaginal misoprostol and letrozole and combination of misoprostol and laminaria for preoperative cervical ripening in under second trimester abortions

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016100923559N6
Enrollment
120
Registered
2016-12-30
Start date
2017-01-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medical abortion. Medical abortion

Interventions

Intervention 1: Intervention group 1: Vaginal misoprostol, produced by Pfizer Company, 600 µg every 4 hours for 5 days in women with the gestational age of 13 weeks or less and 200 µg every 4 hours f
Treatment - Drugs
Intervention group 1: Vaginal misoprostol, produced by Pfizer Company, 600 µg every 4 hours for 5 days in women with the gestational age of 13 weeks or less and 200 µg every 4 hours for 5 days in wom
Intervention group 2: Oral letrozole, produced by Iran Hormon Company, 10 mg daily and vaginal misoprostol, produced by Pfizer Company, 600 µg every 4 hours for 5 days for women in the gestational age
Intervention group 3: vaginal laminaria, produced by Cytotec Company, 5mm for 6 hours and vaginal misoprostol, produced by Pfizer Company, 600 µg every 4 hours for 5 days for women in the gestational

Sponsors

Vice chancellor for research, Ardabil University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Under 20 weeks pregnancy and fetal death. Exclusion criteria: Cesarean section history; adrenal diseases; asthma; history of thromboembolism

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Fetus abortion. Timepoint: Eight hours after the intervention, and every twenty-four hours up to three days if the abortion doesn't occur. Method of measurement: Transvaginal Ultrasonography.

Secondary

MeasureTime frame
Pain. Timepoint: Every four hours until abortion occurs and at the time that abortion occurs. Method of measurement: Visual analog scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahsa Valaee

Ardabil University of Medical Sciences

mshpartovi@gmail.com+98 45 3324 8888

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026