medical treatment of ectopic pregnancy. Tubal pregnancy Fallopian pregnancy
Conditions
Interventions
Intervention 1: In the first group (single dose), we will administer 50 mg/m2 methotrexate IM on day 1, the serum day 4 and 7 ß–hCG will be compared. If there is a drop of 15%, the treatment is consid
Treatment - Drugs
In the first group (single dose), we will administer 50 mg/m2 methotrexate IM on day 1, the serum day 4 and 7 ß–hCG will be compared. If there is a drop of 15%, the treatment is considered effective,
In the second group (double dose), we will administer 50 mg/m2 methotrexate IM on day 1 and 4, the serum day 4 and 7 ß–hCG will be compared. If there is a drop of 15%, the treatment is considered effe
Sponsors
Women's Reproductive Health Research Center, Vice chancellor for research, Tabriz University of Medi
Eligibility
Sex/Gender
Female
Age
15 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are: stable hemodynamic state; adnexal mass diameter lower than 4 cm; the initial ß–hCG lower than 10000 mIU/ml; no fetal heart activity by transvaginal sonography and, the request of fertility preservation. exclusion criteria are: creatinine above 1.5 mg/dl; platelets count lower than 100000/ml; white blood cells count lower than 2000/ml and; increased liver enzymes.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beta-hCG decrease. Timepoint: days 7, 11 and,14. Method of measurement: blood exam. | — |
Secondary
| Measure | Time frame |
|---|---|
| Abdominal pain. Timepoint: daily and per patient report. Method of measurement: by visiting the patient and patient report.;Drug side effects. Timepoint: days 4, 7 and, 11. Method of measurement: physical exam and blood tests. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNazli Navali
Tabriz University of Medical Sciences
Outcome results
None listed