The effect of the tripterygium wilfordii on obesity

The effect of tripterygium wilfordii roots supplementation on the metabolic status, anthropometric parameters and serum levels of leptin and Chemerin in obese women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201610084105N29

Enrollment

Registered

2017-07-01

Start date

2017-07-11

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesity. Obesity due to excess calories

Interventions

Intervention 1: Intervention group: patients will recieve a daily capsule containing 200 mg of tripterygium wilfordii root poweder, for three months. Capsules should taken with food and a glass of wat

Treatment - Drugs

Placebo

Intervention group: patients will recieve a daily capsule containing 200 mg of tripterygium wilfordii root poweder, for three months. Capsules should taken with food and a glass of water.

Control group: patients will receive a placebo capsule, daily for three months..

Eligibility

Sex/Gender

Female

Age

25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 25-50 year old women; BMI of between 30- 40; willingness to cooperate. Exclusion criteria: use of lipid lowering agents; use of body weight loss medications; Addiction and Smoking; Menopause; Sensitivity to placebo; cancer; cardiovascular disease; liver disorders; kidney disease and anemia; use of antioxidant supplements, fish oil supplements and alcohol; pregnancy and lactation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
LDL. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatic and colorimetric method.;Triglyceride. Timepoint: Beginning of the study and after three months. Method of measurement: Enzymatic and colorimetric method.;Total Cholesterol. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatic and colorimetric method.;Serum Chemerin. Timepoint: At baseine and after 3 month of intervention. Method of measurement: ELISA.;Serum Leptin. Timepoint: At baseine and after 3 month of intervention. Method of measurement: ELISA.;BMI. Timepoint: At baseine and after 3 month of intervention. Method of measurement: W/H.t2.;FBS. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Glucose oxidase enzymatic and colorimetric.;Insulin levels. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatically using autoanalyzer.;Insulin resistance. Timepoint: At baseine and after 3 month of intervention. Method of measurement: HOMAIR.;HDL. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatic and colorimetric method.;Whight. Timepoint: At baseine and after 3 month of intervention. Method of measurement: scale.	—

Measure

Time frame

LDL. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatic and colorimetric method.;Triglyceride. Timepoint: Beginning of the study and after three months. Method of measurement: Enzymatic and colorimetric method.;Total Cholesterol. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatic and colorimetric method.;Serum Chemerin. Timepoint: At baseine and after 3 month of intervention. Method of measurement: ELISA.;Serum Leptin. Timepoint: At baseine and after 3 month of intervention. Method of measurement: ELISA.;BMI. Timepoint: At baseine and after 3 month of intervention. Method of measurement: W/H.t2.;FBS. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Glucose oxidase enzymatic and colorimetric.;Insulin levels. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatically using autoanalyzer.;Insulin resistance. Timepoint: At baseine and after 3 month of intervention. Method of measurement: HOMAIR.;HDL. Timepoint: At baseine and after 3 month of intervention. Method of measurement: Enzymatic and colorimetric method.;Whight. Timepoint: At baseine and after 3 month of intervention. Method of measurement: scale.

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Secondary

Measure	Time frame
Food intake. Timepoint: At baseine of the study, sixth week and three months later. Method of measurement: The questionnaires and Software nutrition 4.;Blood pressure. Timepoint: At baseine of the study, sixth week and three months later. Method of measurement: Standard mercury manometer.;Physical activity. Timepoint: At baseine of the study, sixth week and three months later. Method of measurement: The International physical activity questionnaire.	—

Measure

Time frame

Food intake. Timepoint: At baseine of the study, sixth week and three months later. Method of measurement: The questionnaires and Software nutrition 4.;Blood pressure. Timepoint: At baseine of the study, sixth week and three months later. Method of measurement: Standard mercury manometer.;Physical activity. Timepoint: At baseine of the study, sixth week and three months later. Method of measurement: The International physical activity questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mahdi Mousavi Mele

Tabriz University of Medical Sciences

mahdijj8730@gmail.com+98 41 3335 7581

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026