Knee arthrosis. Primary gonarthrosis, bilateral
Conditions
Interventions
Intervention 1: The control group: Who are revising 40 mg of placebo (similar components of curcumin capsules but without curcumin) in 12 hours for 6 weeks. Intervention 2: The intervention group: Who
Treatment - Drugs
The control group: Who are revising 40 mg of placebo (similar components of curcumin capsules but without curcumin) in 12 hours for 6 weeks
The intervention group: Who are revising 40 mg nanomicelle curcumin capsule in 12 hours for 6 weeks.
Sponsors
Vice chancellor for research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Primary knee osteoarthritis with grade II and III base on Kellgren-Lawrence grading scale; having knee pain at least for six months; age between 45 and 65 years; and having primary osteoarthritis. Exclusion criteria: Secondary osteoarthritis (due to trauma); knee arthroscopic surgery in less than six months; use of corticosteroids less than six months; history of allergy; coagulation disorders and coronary heart disease; use of medications affecting coagulation process (e.g., warfarin, heparin, clopidogrel, dipyridamole, and aspirin); genu varum, genu valgus, and pes planus patients; and patients with anserine bursitis
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical outcomes including pain, stiffness, and physical function. Timepoint: Before and 6 weeks after intervention. Method of measurement: Western Ontario and Mcmaster Universities Osteoarthritis Index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic effects. Timepoint: After intervention. Method of measurement: Physical examination and levels of liver transaminases. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNajmeh Davoudian
Emam Reza Hospital
Outcome results
None listed