Poisoning by methadone.
Conditions
Interventions
Intervention 1: Group 1: 3.2, which causes the patient's consciousness was embroidered in the first hour, 3/2 × 3/2 initial dose in the second hour, 3/2 × 3/2 × 3/2 initial dose in the third hour and
Treatment - Drugs
Group 1: 3.2, which causes the patient's consciousness was embroidered in the first hour, 3/2 × 3/2 initial dose in the second hour, 3/2 × 3/2 × 3/2 initial dose in the third hour and 3 / 2 × 3/2 × 3/
Group 2: equivalent dose of naloxone that consciousness is, in the form of Naltrexone receiving oral form.
Sponsors
Vice Chancellor for research of Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 20 to 60 years, obtaining informed consent from a parent or guardian patients into the study. Exclusion criteria: drug, pregnancy and breastfeeding, history of uncontrolled systemic underlying disease, especially liver disease (liver failure, hepatitis, etc.), cardiovascular disease and heart rhythm, especially supraventricular dysrhythmias ; at the same time multiple trauma, especially trauma to the head and the possibility of increased ICP; a history of seizures; a history of hypersensitivity to naloxone or naltrexone consumption in the past; recent use of narcotic analgesics, complications during the administration of a drug abuser
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of consciousness. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Increasing the level of consciousness.;Respiratory function. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Improve respiratory function. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of heart beats per minute. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.;Respiratory rate. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.;Body temperature (° C). Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses.;Systolic and diastolic blood pressure. Timepoint: 1, 2, 3, 4 and 12 hours after intervention. Method of measurement: Measurable clinical responses. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Abolfazl Jokar
Arak University of Medical sceinces
Outcome results
None listed