Evaluation of analgesic efficacy of lidocaine infusion in cesarean section

Effect of intravenous lidocaine on postoperative analgesia in cesarean section under spinal anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201610023051N11

Enrollment

Registered

2016-12-09

Start date

2015-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section. Delivery by caesarean section, unspecified

Interventions

Intervention 1: In control group, we injected bolus dose of Normal Saline intravenously instead of Lidocaine.(in same volume of Lidocaine based on milliliter) 15 min before spinal anesthesia. then mai

Placebo

Treatment - Drugs

In control group, we injected bolus dose of Normal Saline intravenously instead of Lidocaine.(in same volume of Lidocaine based on milliliter) 15 min before spinal anesthesia. then maintenance dose of

In treatment group, 15 minutes before spinal anesthesia, 1.5 mg/kg of bolus Lidocaine 2% injected intravenously then, we infuse maintenance dose of IV Lidocaine 2%(1.5mg/kg/h) and Infusion of drug sho

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : Elective cesarean surgery; patients aged 18 to 45 years, ASA class 1 and 2. Exclusion criteria: complete heart block; Severe bleeding and coagulation disorder; Severe hypotension and shock; septicemia; history of CNS disease; hyperthyroidism; hypertension; history of hepatorenal disease; Cardiovascular disease; diabetes; Allergy to lidocaine; placenta praevia; Placental abruption; cesarean induced deceleration Fetal heart rate (FHR); meconium; addict; contradiction of regional analgesia; eclampsia and preeclampsia; user of Beta blocker and glycoside.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Time to first analgesic requirement. Timepoint: During 24 hrs after the surgery. Method of measurement: Hour.;Sensory block level and recovery of sensory block to T10. Timepoint: 30 and 60 seconds after injection. Method of measurement: Pin prick method.;Motor block level and recovery of motor block. Timepoint: 30 and 60 seconds after injection. Method of measurement: Bromage scale.;Hemodynamic changes (bradycardia, hypotension and Oxygen saturation <90] ). Timepoint: From the time of intervention; every 5 minute until 15 minute then every 15 minute until 1 hour. Method of measurement: Monitoring devise.	—

Measure

Time frame

Time to first analgesic requirement. Timepoint: During 24 hrs after the surgery. Method of measurement: Hour.;Sensory block level and recovery of sensory block to T10. Timepoint: 30 and 60 seconds after injection. Method of measurement: Pin prick method.;Motor block level and recovery of motor block. Timepoint: 30 and 60 seconds after injection. Method of measurement: Bromage scale.;Hemodynamic changes (bradycardia, hypotension and Oxygen saturation <90] ). Timepoint: From the time of intervention; every 5 minute until 15 minute then every 15 minute until 1 hour. Method of measurement: Monitoring devise.

—

Secondary

Measure	Time frame
Secondary effects. Timepoint: During 6 hrs after the surgery. Method of measurement: According patient's history.;Neonate APGAR. Timepoint: In the first and fifth minute from birth. Method of measurement: APGAR criteria.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Rajabi

Qazvin University of Medical Sciences

dr.108162@gmail.comvcrc92@yahoo.com+98 28 3323 6380

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026