Adenotonsilectomy. Hypertrophy of tonsils with hypertrophy of adenoids
Conditions
Interventions
Intervention 1: in group A 15 mg/kg of intravenous acetaminophen in 50 ml normal saline, will be infused 15 minutes before termination of surgery during 10 minutes. Intervention 2: in group D 1 mcg/kg
Treatment - Drugs
Placebo
in group A 15 mg/kg of intravenous acetaminophen in 50 ml normal saline, will be infused 15 minutes before termination of surgery during 10 minutes.
in group D 1 mcg/kg of intravenous dexmedetomidine in 50 ml normal saline, will be infused 15 minutes before termination of surgery during 10 minutes.
in group AD 10 mg/kg of intravenous acetaminophen and 0.3 mcg/kg dexmdetomidine in 50 ml normal saline, will be infused 15 minutes before termination of surgery during 10 minutes.
in group S or control group merely 50 ml normal saline, will be infused 15 minutes before termination of surgery during 10 minutes.
Sponsors
Vice chancellor for research of Kurdistan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: take Informed consent from parents to enter the study; patients between 2-12 old age candidate for Adenotonsilectomy; Physical status 1 and 2 classification of "American Society of Anesthesiologists" (ASA). Exclusion criteria: History of any cardiac, kidney, hepatic, or neurologic (convulsion) disease; Respiratory disease (Asthma or respiratory allergy); History of allergic reaction to the study drugs; History of upper airway infection in the last 4 weeks; use of any type of sedative drugs at the night before surgery; evidence of severe obstractive sleep apenea (OSA)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence agitation. Timepoint: in advent to the recovery room (T0) and in 5,15,30 minutes thereafter and when the patient discharge from PACU. As well as 6 and 24 hours after discharge from PACU. Method of measurement: five score criteria described by Col for evaluate emergence agitation.;Pain. Timepoint: in advent to the recovery room (T0) and in 5,15,30 minutes thereafter and when the patient discharge from PACU. As well as 6 and 24 hours after discharge from PACU. Method of measurement: modified 10 score TPPPS criteria for evaluate of pain in children. | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium. Timepoint: in advent to the recovery room (T0) and in 5,15,30 minutes thereafter and when the patient discharge from PACU. As well as 6 and 24 hours after discharge from PACU. Method of measurement: 20 score PAED criteria for evaluate delirium in children.;Time to need the first rescue analgesic dose. Timepoint: Period of time from PACU admitance until the first need to analgesics. Method of measurement: By recording period of time between PACU admitance to the first need to analgesics.;Rate of need to analgesics. Timepoint: amount of analgesics usage for pain & EA relief. Method of measurement: By recording of amounts of analgesic usage in PACU & ward.;Nausea & vomiting. Timepoint: consideration for beeing Nausea & vomiting. Method of measurement: Have or not have.;Time of stay in PACU. Timepoint: Period of time from admitance to discharge from PACU. Method of measurement: recording period of time from admitance to discharge from PACU based on Aldrete criteria > 9. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Farzad Sarshivi
Kurdistan University of Medical Sciences
Outcome results
None listed