Study of the effects of omega-3 fatty acids supplementation on cigarette craving, urinary cotinine levels and oxidative stress index in heavy smokers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016092929508N5

Enrollment

Registered

2016-12-28

Start date

2016-11-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heavy smoker. Exposure to tobacco smoke

Interventions

Intervention 1: Intervention group: daily 5 gram Omega-3 supplements , for 3 months. Intervention 2: control group: daily 5 gram placebo (miglyol), for 3 months.

Intervention group: daily 5 gram Omega-3 supplements , for 3 months

control group: daily 5 gram placebo (miglyol), for 3 months

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: heavy smokers (a smoker who reports consuming 20 cigarettes or more per day); level of dependence above moderate (Fagerström test for nicotine dependence – FTND = 7 points); depression below mild (Depression Anxiety Stress Scale 21 for depression - DASS 21 5 points); Exclusion criteria:psychiatric and neurodegenerative disorders; abusive use of alcohol or other substances

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Tobacco craving. Timepoint: before intervention, 3 months after intervention. Method of measurement: tobacco craving questionair- short form.;Urinary cotinine. Timepoint: before intervention, 3 months after intervention. Method of measurement: nanogram/liter.;Oxidative stress index. Timepoint: before intervention, 3 months after intervention. Method of measurement: micromol.;Total oxidant status (TOS). Timepoint: before intervention, 3 months after intervention. Method of measurement: µm.;Total antioxidant capacity (TAC). Timepoint: before intervention, 3 months after intervention. Method of measurement: µm.	—

Measure

Time frame

Tobacco craving. Timepoint: before intervention, 3 months after intervention. Method of measurement: tobacco craving questionair- short form.;Urinary cotinine. Timepoint: before intervention, 3 months after intervention. Method of measurement: nanogram/liter.;Oxidative stress index. Timepoint: before intervention, 3 months after intervention. Method of measurement: micromol.;Total oxidant status (TOS). Timepoint: before intervention, 3 months after intervention. Method of measurement: µm.;Total antioxidant capacity (TAC). Timepoint: before intervention, 3 months after intervention. Method of measurement: µm.

—

Secondary

Measure	Time frame
Nicotine dependence. Timepoint: before intervention, 3 months after intervention. Method of measurement: fagesterstrom test.;Sigarette use per day. Timepoint: before intervention, 3 months after intervention. Method of measurement: interview.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Rasoul Zarrin

Urmia University of Medical Sciences

rasoul.zarrin@uqconnect.edu.au; wwzarrin@yahoo.com+98 44 3346 9935

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026