psoriasis. Psoriasis
Conditions
Interventions
Intervention 1: Intervention group: semi-solid formulation (combination of chamomile oil and pumpkin oil in a ratio of 1 to 1) topical treatment twice daily for 4 weeks. Intervention 2: Control group:
Treatment - Drugs
Placebo
Intervention group: semi-solid formulation (combination of chamomile oil and pumpkin oil in a ratio of 1 to 1) topical treatment twice daily for 4 weeks
Control group: Liquid paraffin with 0.1 percent chamomile essence, topical treatment twice daily for 4 weeks
Sponsors
Vice chancellor for research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Years to 60 Years
Inclusion criteria
Inclusion criteria: Main Inclusion criteria: Patients with mild to moderate Psoriasis (less than 10 percent of body surface area); diagnosed by a dermatologist; aged 2-60 years old of both sexes with at least two symmetrical psoriasis plaques in their extensor areas; Discontinuation of topical treatment for at least two weeks prior to the study; Lack of systemic treatment or phototherapy during 4 weeks prior to the study; Absence of skin infections or malignancy in the treatment area; Not using Medications that could Trigger Psoriasis like beta blockers; Taking a written consent form from the patient. Main Exclusion criteria: Lactation; Pregnancy; History of allergy to the active ingredient of the product; History of skin infection or skin malignancy in the treatment area; Allergic reaction to the drug or infection in treatment area; Need to start systemic therapy during the study; Occurrence of events During the study which cause anxiety, Stress or severe mental disturbance in patients; Unwillingness of patients to continue treatment.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scaling, Thickness, Redness. Timepoint: Before treatment and one month later for each lesion. Method of measurement: Compare photos by dermatologist and assign a number from 0 to 8 (0 no symptoms, 2 mild, 4 moderate, 6 severe, 8 very severe) to each of these signs.;PSI score. Timepoint: Before treatment and one month later for each lesion. Method of measurement: The sum of redness, thickness and scaling score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Photography from lesions. Timepoint: Before treatment and one month later for each lesion. Method of measurement: Canon SX60 HS, with 65x zoom and 21-1365 mm eq lens and resolution 17 Megapixels.;Patient and physician overall estimation of treatment success rate. Timepoint: Before treatment and one month later for each lesion. Method of measurement: At the end of the study, both the dermatologist and patient will determine their estimation of improvement rate in each groups of lesions by assigning a number from 0 to ± 100. These numbers will be analyzed in a qualitative manner: negative number: worsening, 0: unchanged, (0-25 %): mild improvement, [25-50%): moderate improvement), [50-75%): high improvement, [75-100%): very high improvement, 100%: full recovery.;Evaluation of possible side effects of formulation and placebo. Timepoint: Two weeks and a month after treatment. Method of measurement: History taking and photography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSima Kolahdooz
Tehran University of Medical Sciences
Outcome results
None listed