Condition 1: organophosphorus poisoning. Condition 2: organophosphorus poisoning. Poisoning by drugs primarily affecting the autonomic nervous system Organophosphate and carbamate insecticides
Conditions
Interventions
Intervention 1: Intervention group receive, Magnesium sulfate 50% at a dose of 2 grams bolus infusion for 30 minutes plus routine treatment, followed by the same dose infusion every 2 hours up to 3 do
Treatment - Drugs
Placebo
Intervention group receive, Magnesium sulfate 50% at a dose of 2 grams bolus infusion for 30 minutes plus routine treatment, followed by the same dose infusion every 2 hours up to 3 doses.
Control group receive placebo (normal saline) as same volume of magnesium sulfate added to routine treatment.
Sponsors
Arak University of Medical Sciences, Vice Chancellor for Research
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age 18 to 65 years old; patients with acute organophosphorus poisoning who do not receive medical care in another medical center; Taking time less than 2 hours after poisoning; Patients satisfaction. Exclusion criteria: Unwillingness to participate in the study; Concomitant use of drugs or other substance accidentally or as a suicidal attempt; History of severe complications or sensitivity to Magnesium sulfate; History of heart block, Myocardial infarction, severe renal failure, Hepatitis and Addison's disease; Patients death.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tracheal secretions. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Respiratory crackle. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Size of pupils. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Deep tendon reflexes. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Salivary secretions. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination.;Fasciculation severity. Timepoint: every 30 minutes after each injection. Method of measurement: Physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function test. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Blood urea nitrogen. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Creatinine. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Serum level of electrolytes. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Blood sugar. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test.;Arterial blood gasses. Timepoint: every 30 minutes after each injection. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Abolfazl Jokar
Vali-e-Asr hospital
Outcome results
None listed