Interval exercise training and the mechanism of reduced blood pressure

The effect of high-intensity interval training on apelin-dependent mechanism in treated hypertension elderly man

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016092823002N3

Enrollment

Registered

2016-10-24

Start date

2016-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Hypertensive diseases

Interventions

Intervention 1: Intervention group 1: 6 interval (1.5 minutes at 85-90 % HR reserve with 2 minutes active interval at 50-55 % HR reserve). Intervention 2: Intervention group 2: 3 interval (3.5 minutes

Rehabilitation

Intervention group 1: 6 interval (1.5 minutes at 85-90 % HR reserve with 2 minutes active interval at 50-55 % HR reserve)

Intervention group 2: 3 interval (3.5 minutes at 85-90% HR reserve with 3.5 minutes at 50-55% HR reserve)

Control group: normal condition without any exercise

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Including criteria: treated hypertension elderly men; no any participant to regular exercise training for 1 year and exclusion criteria will be: body mass index >28; cardiovascular disease; liver and kidney disease; mental disease; functional limitation( such as osteoarthritis) and cessation of drug use during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Apelin. Timepoint: Before and after 6 week of intervention. Method of measurement: ELISA.;Nitrate/nitrite. Timepoint: Before and after 6 week of intervention. Method of measurement: ELISA.;VO2 peak. Timepoint: Before and after 6 week of intervention. Method of measurement: Gas analyser.;Resting heart rate. Timepoint: Before and after 6 week of intervention. Method of measurement: Polar beat heart rate.;Systolic and diastolic blood pressure. Timepoint: Before and after 6 week of intervention (rest, exercise, recovery). Method of measurement: sphygmomanometer.;Fat percent. Timepoint: Before and after 6 week of intervention. Method of measurement: Caliper- Jackson and Pollock’s Equation.;Endothelin-1. Timepoint: Before and after 6 week of intervention. Method of measurement: ELISA.;Maximal heart rate. Timepoint: Before and after 6 week of intervention. Method of measurement: Polar beat heart rate.;Recovery heart rate. Timepoint: Before and after 6 week of intervention (1,2,3 minutes recovery). Method of measurement: Polar beat heart rate.	—

Measure

Time frame

Apelin. Timepoint: Before and after 6 week of intervention. Method of measurement: ELISA.;Nitrate/nitrite. Timepoint: Before and after 6 week of intervention. Method of measurement: ELISA.;VO2 peak. Timepoint: Before and after 6 week of intervention. Method of measurement: Gas analyser.;Resting heart rate. Timepoint: Before and after 6 week of intervention. Method of measurement: Polar beat heart rate.;Systolic and diastolic blood pressure. Timepoint: Before and after 6 week of intervention (rest, exercise, recovery). Method of measurement: sphygmomanometer.;Fat percent. Timepoint: Before and after 6 week of intervention. Method of measurement: Caliper- Jackson and Pollock’s Equation.;Endothelin-1. Timepoint: Before and after 6 week of intervention. Method of measurement: ELISA.;Maximal heart rate. Timepoint: Before and after 6 week of intervention. Method of measurement: Polar beat heart rate.;Recovery heart rate. Timepoint: Before and after 6 week of intervention (1,2,3 minutes recovery). Method of measurement: Polar beat heart rate.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Ghardashi

University of Tehran

ghardashi.a@ut.ac.ir+98 21 8201 5031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026