Depression phase of bipolar disorder. Bipolar affective disorder, current episode mild or moderate depression
Conditions
Interventions
Intervention 1: intervention group: 200mg coenzyme Q10 twice daily plus standard treatment of bipolar depression for 8 weeks. Intervention 2: Control group: Placebo plus standard treatment for bipola
Treatment - Drugs
Placebo
intervention group: 200mg coenzyme Q10 twice daily plus standard treatment of bipolar depression for 8 weeks
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients between 18-65 years old; patients with diagnosed bipolar depression based on DSM-5 and MADRS score equal to or more than 7 exclusion criteria: patients with anxiety disorder not related to bipolar disorder; patients with mixed episodes of depression and manic or hypomanic phase; patients with severe disease; patients who administrated antidepressant agents during 1 month ago; patients who adminsitrated any antioxidant agents or supplements during 1 month ago; patients who did not administrated drug or placebo regularly at least in 80% of study duration; pregnant patients; nursing patients
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression severity. Timepoint: before the intervention, at the 4th week of intervention, at the 8th week of intervention. Method of measurement: MADRS. | — |
Secondary
| Measure | Time frame |
|---|---|
| -. Timepoint: -. Method of measurement: -. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed