HIV. Unspecified human immunodeficiency virus [HIV] disease
Conditions
Interventions
Intervention 1: Zist Takhmir Company probiotic capsules containing ( Lactobacillus Rhamnosus GR-1 and Lactobacil lus Reuteri RC-14 10 ^ 9 colony forming units ), one capsule every 12 hours for 24 we
Treatment - Drugs
Placebo
Zist Takhmir Company probiotic capsules containing ( Lactobacillus Rhamnosus GR-1 and Lactobacil lus Reuteri RC-14 10 ^ 9 colony forming units ), one capsule every 12 hours for 24 weeks.
One Placebo capsule every 12 hours for 4 weeks
Sponsors
Vice chancellor for research Tehran University of Medical Sciences
Zist Takhmir Company
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Confirm HIV infection by Western blot analysis; lack of criteria for initiating treatment according to national HIV guideline; no use of probiotic supplements in the past 6 months ; have a consent to conduct research Exclusion criteria:On Highly Active Anti Retroviral Therapy (HAART) regimens; active addiction; opportunistic infection in the past; Liver or Kidney failure; inflammatory bowel disease and other well known Gastrointestinal pathology; active infection and fever; younger than 18 and older than 65 years; have a cancer, pregnancy and breastfeeding; being dependent on alcohol; a history of allergy or sensitivity to the probiotic or lactose intolerance; use of other supplement drugs, and multivitamins; Use of growth hormone, testosterone or anabolic agent during the last 6 months.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4. Timepoint: At baseline ,three months later, and after 6 months. Method of measurement: Based on the number per microliter by laboratory blood tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP. Timepoint: At baseline ,three months later, and after 6 months. Method of measurement: Based on the number per microliter by laboratory blood tests.;Side effects. Timepoint: every 4 week after intervention. Method of measurement: Based on side effects checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Asadollahi Amin
Tehran University of Medical Science
Outcome results
None listed