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Effect of Colchicine on aphthous ulceration.

Investigation the clinical efficacy of Colchicine-loaded polymeric nanofibers on aphthous ulceration, A Pilot Study

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160920029889N4
Enrollment
10
Registered
2023-01-07
Start date
2023-01-14
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aphthous. Recurrent oral aphthae

Interventions

Intervention 1: Intervention group: A circular piece of polymer nanofibers with a diameter of 1.2 cm containing 1 mg of colchicine is prescribed to each patient and he will be taught to place the piec

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age range between 20 and 40 years No more than a day has passed since the beginning of aphthous ulcers Not using another treatment method for your aphthous lesions before visiting No history of known systemic disease associated with aphthous ulcers Not having suspicious symptoms of systemic diseases related to aphthous ulcers

Exclusion criteria

Exclusion criteria: Recent use of colchicine Using another drug simultaneously with the drugs prescribed to treat the pest Not to use the medicine as recommended according to the patient's own statements Failure to return the patient for re-examination The presence of lesions in the area of ??the tonsils and the posterior 1/3 of the mouth Concomitant use of immunosuppressive drugs Lactating and pregnant women

Design outcomes

Primary

MeasureTime frame
Pain score. Timepoint: Before and 7 days after the start of treatment. Method of measurement: Visual Analogue Scale.;Size of the lesion. Timepoint: Before and 7 days after the start of treatment. Method of measurement: Graph paper.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Morad

Mazandaran University of Medical Sciences

h.morad@mazums.ac.ir+98 11 5522 5151

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026