Comparison of Low & Conventional Bupivacaine dose On blood Pressure changes in severe Preeclamptic patients

Comparison of spinal anesthesia with Low & Conventional Bupivacaine dose On blood Pressure changes in severe Preeclamptic patients Candidate for cesarean section

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016091714056N9

Enrollment

Registered

2016-09-27

Start date

2016-05-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe preeclampsia. Severe pre-eclampsia

Interventions

Intervention 1: Intervention: Group 1 receive lower dose of Bupivacaine 0.5 %( 7.5 mg). Intervention 2: Control: Group 2 receive conventional dose of Bupivacaine 0.5 %( 12.5 mg).

Treatment - Drugs

Intervention: Group 1 receive lower dose of Bupivacaine 0.5 %( 7.5 mg).

Control: Group 2 receive conventional dose of Bupivacaine 0.5 %( 12.5 mg)

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with severe preeclampsia and candidate for caesarian section under spinal anesthesia; ASA I or II; Platelet greater than or equal to 100000; No History of sensitivity to the local anesthetic drug. Exclusion criteria: Failure in spinal anesthesia; Uncooperative patient in determining the sensory level; Heart failure; Active bleeding; History of renal or hepatic failure; Intracranial hemorrhage or stroke; Neurologic diseases; Psychiatric disorders(Schizophrenia; schizoaffective disorder; schizophreniform disorder; Bipolar disorder); ASA greater than or equal 3

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: sphygmomanometer.;Diastolic blood pressure. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: sphygmomanometer.;Mean arterial pressure. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: sphygmomanometer.;Pulse rate. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: pulse rate per minute.;Oxygen saturation. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: Puse oximeter.	—

Measure

Time frame

Systolic blood pressure. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: sphygmomanometer.;Diastolic blood pressure. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: sphygmomanometer.;Mean arterial pressure. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: sphygmomanometer.;Pulse rate. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: pulse rate per minute.;Oxygen saturation. Timepoint: before and after spinal anesthesia and every 5 minutes until end of operation. Method of measurement: Puse oximeter.

—

Secondary

Measure	Time frame
Apgar score. Timepoint: at 1 and 5 minutes after birth. Method of measurement: Questionare.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesameddin Modir

Arak University of Medical Sciences

He_modir@yahoo.com+98 86 3417 3641

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026