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Efficacy of topical baclofen in the reduction of postoperative pain after hemorrhoidectomy

Efficacy of baclofen 5% cream in the reduction of postoperative pain after open hemorrhoidectomy: a prospective, double-Blind, randomized, placebo controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201609163014N16
Enrollment
60
Registered
2017-01-07
Start date
2016-09-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hemorrhoids. External haemorrhoids with other complications

Interventions

Intervention 1: Intervention: Baclofen 5% cream, twice daily until one month plus acetaminophen 325 mg tablets three times daily. Intervention 2: Control: Placebo cream, without active ingredient, twi
Treatment - Drugs
Intervention: Baclofen 5% cream, twice daily until one month plus acetaminophen 325 mg tablets three times daily
Control: Placebo cream, without active ingredient, twice daily until one month plus acetaminophen 325 mg tablets three times daily

Sponsors

Vice Chancellor of Research, Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 20 and 70 years; candidate for hemorroidectomy surgery Exclusion criteria: Hypersensivity to baclofen; develop ulcer size; taking oral baclofen

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain intensity. Timepoint: 7th, 14th, 21th, 28th day after surgery. Method of measurement: Visual analog scale.—

Secondary

MeasureTime frame
Side effects. Timepoint: 7th, 14th, 21th, 28th day after surgery. Method of measurement: Questionnarie.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Shahram Ala

Mazandaran University of Medical Science, Faculty of Pharmacy

sala@mazums.ac.ir+98 11 3354 3082

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026